Literature DB >> 23646061

Epigenetic Modulations of Induced Pluripotent Stem Cells: Novel Therapies and Disease Models.

Chengyang Huang1, Joseph C Wu.   

Abstract

Recent breakthroughs in induced pluripotent stem cell (iPSC) technology hold promise for novel cell-based therapies as well as for effective drug development. The therapeutic potential of iPSCs makes it important to understand the reprogramming mechanisms and iPSC differentiation process. Epigenetic states that mediate exogenous stimulations on cell-intrinsic transcriptional features play a key role in iPSCs. This review focuses on epigenetic mechanisms that control iPSC pluripotency and differentiation. We discuss the potential application of epigenetic modulations in development of iPSC-based therapies and disease models.

Entities:  

Keywords:  Induced pluripotent stem cells; disease model; embryonic stem cells; epigenetic modulation; reprogramming

Year:  2012        PMID： 23646061      PMCID： PMC3640613          DOI： 10.1016/j.ddmod.2012.02.004

Source DB:  PubMed          Journal:  Drug Discov Today Dis Models        ISSN： 1740-6757


  66 in total

1.  Recreating pluripotency?

Authors:  Kyle M Loh; Bing Lim
Journal:  Cell Stem Cell       Date:  2010-08-06       Impact factor: 24.633

Review 2.  Histone H3 Lys 4 methylation: caught in a bind?

Authors:  Robert J Sims; Danny Reinberg
Journal:  Genes Dev       Date:  2006-10-15       Impact factor: 11.361

3.  Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells.

Authors:  Timothy J Nelson; Almudena Martinez-Fernandez; Satsuki Yamada; Carmen Perez-Terzic; Yasuhiro Ikeda; Andre Terzic
Journal:  Circulation       Date:  2009-07-20       Impact factor: 29.690

Review 4.  Advances in the computational development of DNA methyltransferase inhibitors.

Authors:  José L Medina-Franco; Thomas Caulfield
Journal:  Drug Discov Today       Date:  2011-02-16       Impact factor: 7.851

5.  Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors.

Authors:  Hiroshi Ban; Naoki Nishishita; Noemi Fusaki; Toshiaki Tabata; Koichi Saeki; Masayuki Shikamura; Nozomi Takada; Makoto Inoue; Mamoru Hasegawa; Shin Kawamata; Shin-Ichi Nishikawa
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-05       Impact factor: 11.205

6.  PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.

Authors:  Zhuo Zhang; Amanda Jones; Chiao-Wang Sun; Chao Li; Chia-Wei Chang; Heui-Yun Joo; Qian Dai; Matthew R Mysliwiec; Li-Chen Wu; Yahong Guo; Wei Yang; Kaimao Liu; Kevin M Pawlik; Hediye Erdjument-Bromage; Paul Tempst; Youngsook Lee; Jinrong Min; Tim M Townes; Hengbin Wang
Journal:  Stem Cells       Date:  2011-02       Impact factor: 6.277

7.  Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.

Authors:  Frederick Anokye-Danso; Chinmay M Trivedi; Denise Juhr; Mudit Gupta; Zheng Cui; Ying Tian; Yuzhen Zhang; Wenli Yang; Peter J Gruber; Jonathan A Epstein; Edward E Morrisey
Journal:  Cell Stem Cell       Date:  2011-04-08       Impact factor: 24.633

8.  Reprogramming of human somatic cells to pluripotency with defined factors.

Authors:  In-Hyun Park; Rui Zhao; Jason A West; Akiko Yabuuchi; Hongguang Huo; Tan A Ince; Paul H Lerou; M William Lensch; George Q Daley
Journal:  Nature       Date:  2007-12-23       Impact factor: 49.962

9.  In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Authors:  Marius Wernig; Alexander Meissner; Ruth Foreman; Tobias Brambrink; Manching Ku; Konrad Hochedlinger; Bradley E Bernstein; Rudolf Jaenisch
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

10.  Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.

Authors:  Rutger-Jan Swijnenburg; Sonja Schrepfer; Johannes A Govaert; Feng Cao; Katie Ransohoff; Ahmad Y Sheikh; Munif Haddad; Andrew J Connolly; Mark M Davis; Robert C Robbins; Joseph C Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-26       Impact factor: 11.205
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  2 in total

Review 1.  Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives.

Authors:  Maggie Chow; Kenneth R Boheler; Ronald A Li
Journal:  Stem Cell Res Ther       Date:  2013-08-14       Impact factor: 6.832

Review 2.  "Cutting the Mustard" with Induced Pluripotent Stem Cells: An Overview and Applications in Healthcare Paradigm.

Authors:  Tapan Behl; Ishnoor Kaur; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Sridevi Chigurupati; Shatha Ghazi Felemban; Amal M Alsubayiel; Muhammad Shahid Iqbal; Saurabh Bhatia; Ahmed Al-Harrasi; Simona Bungau; Ebrahim Mostafavi
Journal:  Stem Cell Rev Rep       Date:  2022-07-06       Impact factor: 5.739
  2 in total

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