Literature DB >> 23634735

Targeting IL-15 in large granular lymphocyte leukemia.

Steven N Steinway1, Thomas P Loughran.   

Abstract

IL-15 is a cytokine that stimulates the proliferation of NK and T cells. Previous studies have shown that IL-15 is critical to the induction of T-cell large granular lymphocyte (T-LGL) leukemia. A Phase I trial of a humanized antibody (Hu-Mikβ1) to the IL2/IL15Rβ receptor, expressed on T-LGL, is explored in this trial to evaluate the safety, pharmacokinetics, specificity and clinical efficacy of Hu-Mikβ1. The study demonstrated no toxicity and favorable saturation of IL2/IL15Rβ receptor, but no clinical efficacy in this Phase I study.

Entities:  

Year:  2013        PMID： 23634735      PMCID： PMC3889194          DOI： 10.1586/eci.13.28

Source DB:  PubMed          Journal:  Expert Rev Clin Immunol        ISSN： 1744-666X            Impact factor:   4.473


  15 in total

Review 1.  Pathophysiology defined by altered signal transduction pathways: the role of JAK-STAT and PI3K signaling in leukemic large granular lymphocytes.

Authors:  Andrew E Schade; Marcin W Wlodarski; Jaroslaw P Maciejewski
Journal:  Cell Cycle       Date:  2006-11-15       Impact factor: 4.534

Review 2.  Regulation of lymphoid homeostasis by interleukin-15.

Authors:  James P Lodolce; Patrick R Burkett; Rima M Koka; David L Boone; Averil Ma
Journal:  Cytokine Growth Factor Rev       Date:  2002-12       Impact factor: 7.638

3.  Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia.

Authors:  Jing Chen; Mike Petrus; Richard Bamford; Joanna H Shih; John C Morris; John E Janik; Thomas A Waldmann
Journal:  Blood       Date:  2011-11-02       Impact factor: 22.113

4.  Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia.

Authors:  John C Morris; John E Janik; Jeffrey D White; Thomas A Fleisher; Margaret Brown; Mitsuru Tsudo; Carolyn K Goldman; Bonita Bryant; Michael Petrus; Lois Top; Cathryn C Lee; Wendy Gao; Thomas A Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-30       Impact factor: 11.205

5.  Spontaneous findings in the heart of Mauritian-origin cynomolgus macaques (Macaca fascicularis).

Authors:  Justin D Vidal; Lita S Drobatz; Denise F Holliday; Lee E Geiger; Heath C Thomas
Journal:  Toxicol Pathol       Date:  2010-02-02       Impact factor: 1.902

6.  Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation.

Authors:  Anjali Mishra; Shujun Liu; Gregory H Sams; Douglas P Curphey; Ramasamy Santhanam; Laura J Rush; Deanna Schaefer; Lauren G Falkenberg; Laura Sullivan; Laura Jaroncyk; Xiaojuan Yang; Harold Fisk; Lai-Chu Wu; Christopher Hickey; Jason C Chandler; Yue-Zhong Wu; Nyla A Heerema; Kenneth K Chan; Danilo Perrotti; Jianying Zhang; Pierluigi Porcu; Frederick K Racke; Ramiro Garzon; Robert J Lee; Guido Marcucci; Michael A Caligiuri
Journal:  Cancer Cell       Date:  2012-11-13       Impact factor: 31.743

7.  Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC.

Authors:  J Hakimi; V C Ha; P Lin; E Campbell; M K Gately; M Tsudo; P W Payne; T A Waldmann; A J Grant; W H Tsien
Journal:  J Immunol       Date:  1993-07-15       Impact factor: 5.422

8.  Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes.

Authors:  Mithun Vinod Shah; Ranran Zhang; Rosalyn Irby; Ravi Kothapalli; Xin Liu; Ty Arrington; Bryan Frank; Norman H Lee; Thomas P Loughran
Journal:  Blood       Date:  2008-05-13       Impact factor: 22.113

9.  Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia.

Authors:  Sanjay R Mohan; Michael J Clemente; Manuel Afable; Heather N Cazzolli; Nelli Bejanyan; Marcin W Wlodarski; Alan E Lichtin; Jaroslaw P Maciejewski
Journal:  Haematologica       Date:  2009-10       Impact factor: 9.941

10.  STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.

Authors:  Andres Jerez; Michael J Clemente; Hideki Makishima; Hanna Koskela; Francis Leblanc; Kwok Peng Ng; Thomas Olson; Bartlomiej Przychodzen; Manuel Afable; Ines Gomez-Segui; Kathryn Guinta; Lisa Durkin; Eric D Hsi; Kathy McGraw; Dan Zhang; Marcin W Wlodarski; Kimmo Porkka; Mikkael A Sekeres; Alan List; Satu Mustjoki; Thomas P Loughran; Jaroslaw P Maciejewski
Journal:  Blood       Date:  2012-08-02       Impact factor: 22.113
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  3 in total

Review 1.  The pathogenesis and treatment of large granular lymphocyte leukemia.

Authors:  Steven Nathaniel Steinway; Francis LeBlanc; Thomas P Loughran
Journal:  Blood Rev       Date:  2014-03-07       Impact factor: 8.250

Review 2.  Inclusion Body Myositis and Neoplasia: A Narrative Review.

Authors:  Laura Damian; Cristian Cezar Login; Carolina Solomon; Cristina Belizna; Svetlana Encica; Laura Urian; Ciprian Jurcut; Bogdan Stancu; Romana Vulturar
Journal:  Int J Mol Sci       Date:  2022-07-01       Impact factor: 6.208

3.  Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates.

Authors:  Yunier Rodríguez-Álvarez; Yanelys Morera-Díaz; Haydee Gerónimo-Pérez; Jorge Castro-Velazco; Rafael Martínez-Castillo; Pedro Puente-Pérez; Vladimir Besada-Pérez; Eugenio Hardy-Rando; Araceli Chico-Capote; Klaudia Martínez-Cordovez; Alicia Santos-Savio
Journal:  BMC Immunol       Date:  2016-09-26       Impact factor: 3.615
  3 in total

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