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Literature DB >> 12401478

Regulation of lymphoid homeostasis by interleukin-15.

James P Lodolce¹, Patrick R Burkett, Rima M Koka, David L Boone, Averil Ma.

Abstract

Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis. Copyright 2002 Elsevier Science Ltd.

Entities: Disease Gene Species

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Year: 2002 PMID： 12401478 DOI： 10.1016/s1359-6101(02)00029-1

Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638

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Cited

31 in total

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Authors: John J Powers; Jason A Dubovsky; P K Epling-Burnette; Lynn Moscinski; Ling Zhang; Satu Mustjoki; Eduardo M Sotomayor; Javier A Pinilla-Ibarz
Journal: Leuk Lymphoma Date: 2011-01-27

2. The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells.

Authors: Noriko Sato; Hiral J Patel; Thomas A Waldmann; Yutaka Tagaya
Journal: Proc Natl Acad Sci U S A Date: 2007-01-03 Impact factor: 11.205

3. The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.

Authors: Zheng Wu; Hai-Hui Xue; Jérôme Bernard; Rong Zeng; Dmitry Issakov; Julie Bollenbacher-Reilley; Igor M Belyakov; Sangkon Oh; Jay A Berzofsky; Warren J Leonard
Journal: Blood Date: 2008-09-16 Impact factor: 22.113

4. The IL-15 cytokine system provides growth and survival signals in Hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells.

Authors: K Ullrich; F Blumenthal-Barby; B Lamprecht; K Köchert; D Lenze; M Hummel; S Mathas; B Dörken; M Janz
Journal: Leukemia Date: 2014-12-09 Impact factor: 11.528

Regulation of lymphoid homeostasis by interleukin-15.

1. A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors.

2. The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells.

3. The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.

4. The IL-15 cytokine system provides growth and survival signals in Hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells.

5. IL-15 regulates susceptibility of CD4⁺ T cells to HIV infection.

Review 6. The pathogenesis and treatment of large granular lymphocyte leukemia.

Review 7. Cytokine Signaling in the Development and Homeostasis of Regulatory T cells.

8. Intestinal overexpression of interleukin (IL)-15 promotes tissue eosinophilia and goblet cell hyperplasia.

Review 9. Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review.

10. The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia.