STUDY OBJECTIVES: We assessed the relationship between sleep duration, snoring and colorectal cancer risk. DESIGN: Prospective cohort studies. SETTING: United States. PARTICIPANTS: A total of 30,121 men aged 41 to 79 years in the Health Professionals Follow-up Study and 76,368 women aged 40 to 73 years in the Nurses' Health Study. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: We queried information on sleep duration and snoring in 1986/87. Cox proportional hazards regression models were used to estimate multivariable hazard ratios (HRs, 95% CIs). We documented 1,973 incident colorectal cancer cases (709 men and 1,264 women) over a 22-year follow-up period. Compared to sleep an average 7 h, ≥ 9 h of sleep was significantly associated with a higher risk of colorectal cancer among men (HR = 1.35, 95% CI: 1.00, 1.82), and to a lesser degree, among women (HR = 1.11, 95% CI: 0.85, 1.44). The risk associated with longer sleep was restricted to individuals who regularly snored (men: HR = 1.80, 95% CI: 1.14, 2.84; women: HR = 2.32, 95% CI: 1.24, 4.36) and to overweight individuals (i.e., BMI ≥ 25 kg/m2) (men: HR = 1.52, 95% CI: 1.04, 2.21; women: HR = 1.37, 95% CI: 0.97, 1.94). Short sleep duration (≤ 5 h) was not associated with an increased risk of colorectal cancer in the entire sample or in subgroups stratified by snoring or BMI. CONCLUSIONS: Longer sleep duration was associated with an increased risk of developing colorectal cancer among individuals who were overweight or snored regularly. This observation raises the possibility that sleep apnea and its attendant intermittent hypoxemia may contribute to cancer risk.
STUDY OBJECTIVES: We assessed the relationship between sleep duration, snoring and colorectal cancer risk. DESIGN: Prospective cohort studies. SETTING: United States. PARTICIPANTS: A total of 30,121 men aged 41 to 79 years in the Health Professionals Follow-up Study and 76,368 women aged 40 to 73 years in the Nurses' Health Study. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: We queried information on sleep duration and snoring in 1986/87. Cox proportional hazards regression models were used to estimate multivariable hazard ratios (HRs, 95% CIs). We documented 1,973 incident colorectal cancer cases (709 men and 1,264 women) over a 22-year follow-up period. Compared to sleep an average 7 h, ≥ 9 h of sleep was significantly associated with a higher risk of colorectal cancer among men (HR = 1.35, 95% CI: 1.00, 1.82), and to a lesser degree, among women (HR = 1.11, 95% CI: 0.85, 1.44). The risk associated with longer sleep was restricted to individuals who regularly snored (men: HR = 1.80, 95% CI: 1.14, 2.84; women: HR = 2.32, 95% CI: 1.24, 4.36) and to overweight individuals (i.e., BMI ≥ 25 kg/m2) (men: HR = 1.52, 95% CI: 1.04, 2.21; women: HR = 1.37, 95% CI: 0.97, 1.94). Short sleep duration (≤ 5 h) was not associated with an increased risk of colorectal cancer in the entire sample or in subgroups stratified by snoring or BMI. CONCLUSIONS: Longer sleep duration was associated with an increased risk of developing colorectal cancer among individuals who were overweight or snored regularly. This observation raises the possibility that sleep apnea and its attendant intermittent hypoxemia may contribute to cancer risk.
Authors: I Almendros; J M Montserrat; J Ramírez; M Torres; J Duran-Cantolla; D Navajas; R Farré Journal: Eur Respir J Date: 2012-01 Impact factor: 16.671
Authors: F Javier Nieto; Paul E Peppard; Terry Young; Laurel Finn; Khin Mae Hla; Ramon Farré Journal: Am J Respir Crit Care Med Date: 2012-05-20 Impact factor: 21.405
Authors: M Kakizaki; S Kuriyama; T Sone; K Ohmori-Matsuda; A Hozawa; N Nakaya; S Fukudo; I Tsuji Journal: Br J Cancer Date: 2008-09-23 Impact factor: 7.640
Authors: Timothy I Morgenthaler; Janet B Croft; Leslie C Dort; Lauren D Loeding; Janet M Mullington; Sherene M Thomas Journal: J Clin Sleep Med Date: 2015-09-15 Impact factor: 4.062
Authors: Nathaniel F Watson; M Safwan Badr; Gregory Belenky; Donald L Bliwise; Orfeu M Buxton; Daniel Buysse; David F Dinges; James Gangwisch; Michael A Grandner; Clete Kushida; Raman K Malhotra; Jennifer L Martin; Sanjay R Patel; Stuart F Quan; Esra Tasali Journal: J Clin Sleep Med Date: 2015-08-15 Impact factor: 4.062
Authors: Jeffrey M Cohen; Yunhui T Li; Shaowei Wu; Jiali Han; Abrar A Qureshi; Eunyoung Cho Journal: Int J Dermatol Date: 2015-08-14 Impact factor: 2.736
Authors: Nathaniel F Watson; M Safwan Badr; Gregory Belenky; Donald L Bliwise; Orfeu M Buxton; Daniel Buysse; David F Dinges; James Gangwisch; Michael A Grandner; Clete Kushida; Raman K Malhotra; Jennifer L Martin; Sanjay R Patel; Stuart F Quan; Esra Tasali Journal: Sleep Date: 2015-08-01 Impact factor: 5.849
Authors: Ashwin N Ananthakrishnan; Hamed Khalili; Gauree G Konijeti; Leslie M Higuchi; Punyanganie de Silva; Charles S Fuchs; James M Richter; Eva S Schernhammer; Andrew T Chan Journal: Clin Gastroenterol Hepatol Date: 2014-04-26 Impact factor: 11.382
Authors: Amanda I Phipps; Parveen Bhatti; Marian L Neuhouser; Chu Chen; Tracy E Crane; Candyce H Kroenke; Heather Ochs-Balcom; Michelle Rissling; Beverly M Snively; Marcia L Stefanick; Miriam M Treggiari; Nathaniel F Watson Journal: J Clin Sleep Med Date: 2016-04-15 Impact factor: 4.062