U J Gunnerud1, E M Ostman, I M E Björck. 1. Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden. ulrika.gunnerud@appliednutrition.lth.se
Abstract
BACKGROUND/ OBJECTIVES:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses. SUBJECTS/ METHODS:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference. RESULTS: Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P ≤ 0.05). The 18 g dose significantly increased the insulin response (iAUC 0-120 min; P ≤ 0.05). All measured plasma AAs (15 in total), except glutamic acid, responded in a dose-dependent way, and the 9 and 18 g doses resulted in significantly higher plasma levels of AAs compared with the reference. CONCLUSIONS:Whey protein affects glycaemia, insulinaemia and plasma AAs to a glucose load in a dose-dependent manner. Comparatively low doses of whey protein (9 g) reduced postprandial glycaemia significantly when added to a carbohydrate-rich meal.
RCT Entities:
BACKGROUND/ OBJECTIVES: Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses. SUBJECTS/ METHODS: Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference. RESULTS: Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P ≤ 0.05). The 18 g dose significantly increased the insulin response (iAUC 0-120 min; P ≤ 0.05). All measured plasma AAs (15 in total), except glutamic acid, responded in a dose-dependent way, and the 9 and 18 g doses resulted in significantly higher plasma levels of AAs compared with the reference. CONCLUSIONS: Whey protein affects glycaemia, insulinaemia and plasma AAs to a glucose load in a dose-dependent manner. Comparatively low doses of whey protein (9 g) reduced postprandial glycaemia significantly when added to a carbohydrate-rich meal.
Authors: Rachel A Elovaris; Vida Bitarafan; Shahram Agah; Sina S Ullrich; Kylie Lange; Michael Horowitz; Christine Feinle-Bisset Journal: Nutrients Date: 2021-05-11 Impact factor: 5.717