Literature DB >> 23630137

Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction.

Yong Yang1, Jianliang Shen, Xujiang Yu, Guoting Qin, Mingzhen Zhang, Haifa Shen, Zongwan Mao, Mauro Ferrari.   

Abstract

Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23630137      PMCID： PMC3940256          DOI： 10.1002/cbic.201300082

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  30 in total

1.  Monitoring molecular beacon DNA probe hybridization at the single-molecule level.

Authors:  Gang Yao; Xiaohong Fang; Hiroaki Yokota; Toshio Yanagida; Weihong Tan
Journal:  Chemistry       Date:  2003-11-21       Impact factor: 5.236

Review 2.  Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention.

Authors:  Vladimir N Anisimov
Journal:  Exp Gerontol       Date:  2003-10       Impact factor: 4.032

3.  Structure of the insulin receptor ectodomain reveals a folded-over conformation.

Authors:  Neil M McKern; Michael C Lawrence; Victor A Streltsov; Mei-Zhen Lou; Timothy E Adams; George O Lovrecz; Thomas C Elleman; Kim M Richards; John D Bentley; Patricia A Pilling; Peter A Hoyne; Kellie A Cartledge; Tam M Pham; Jennifer L Lewis; Sonia E Sankovich; Violet Stoichevska; Elizabeth Da Silva; Christine P Robinson; Maurice J Frenkel; Lindsay G Sparrow; Ross T Fernley; V Chandana Epa; Colin W Ward
Journal:  Nature       Date:  2006-09-06       Impact factor: 49.962

4.  Subunit counting in membrane-bound proteins.

Authors:  Maximilian H Ulbrich; Ehud Y Isacoff
Journal:  Nat Methods       Date:  2007-03-18       Impact factor: 28.547

5.  Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor.

Authors:  V Chandana Epa; Colin W Ward
Journal:  Protein Eng Des Sel       Date:  2006-06-13       Impact factor: 1.650

6.  The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript.

Authors:  Erin A Bohula; Amanda J Salisbury; Muhammad Sohail; Martin P Playford; Johann Riedemann; Edwin M Southern; Valentine M Macaulay
Journal:  J Biol Chem       Date:  2003-02-24       Impact factor: 5.157

7.  Single-molecule force spectroscopy study of interaction between transforming growth factor beta1 and its receptor in living cells.

Authors:  Junping Yu; Qiang Wang; Xiaoli Shi; Xinyong Ma; Huayan Yang; Ye-Guang Chen; Xiaohong Fang
Journal:  J Phys Chem B       Date:  2007-11-13       Impact factor: 2.991

8.  Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer.

Authors:  Yongfen Min; Yasushi Adachi; Hiroyuki Yamamoto; Hideto Ito; Fumio Itoh; Choon-Taek Lee; Sorena Nadaf; David P Carbone; Kohzoh Imai
Journal:  Cancer Res       Date:  2003-10-01       Impact factor: 12.701

9.  Antitumor activity of GSK1904529A, a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase.

Authors:  Peter Sabbatini; Jason L Rowand; Arthur Groy; Susan Korenchuk; Qi Liu; Charity Atkins; Melissa Dumble; Jingsong Yang; Kelly Anderson; Brian J Wilson; Kyle A Emmitte; Sridhar K Rabindran; Rakesh Kumar
Journal:  Clin Cancer Res       Date:  2009-04-21       Impact factor: 12.531

10.  Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors.

Authors:  Paul Haluska; Heather M Shaw; Gretchen N Batzel; Donghua Yin; Julian R Molina; L Rhoda Molife; Timothy A Yap; M Luisa Roberts; Amarnath Sharma; Antonio Gualberto; Alex A Adjei; Johann S de Bono
Journal:  Clin Cancer Res       Date:  2007-10-01       Impact factor: 12.531
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  2 in total

Review 1.  Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness and Molecular Mechanisms of Action During Accelerated Biological Aging.

Authors:  Ye Chen; Sherif Hamidu; Xintong Yang; Yiqi Yan; Qilong Wang; Lin Li; Patrick Kwabena Oduro; Yuhong Li
Journal:  Front Genet       Date:  2022-04-28       Impact factor: 4.772

2.  The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.

Authors:  Wooseong Kim; Guijin Zou; Wen Pan; Nico Fricke; Hammad A Faizi; Soo Min Kim; Rajamohammed Khader; Silei Li; Kiho Lee; Iliana Escorba; Petia M Vlahovska; Huajian Gao; Frederick M Ausubel; Eleftherios Mylonakis
Journal:  mBio       Date:  2020-06-30       Impact factor: 7.867
  2 in total

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