OBJECTIVE: Obesity is as an independent risk factor for poor neurocognitive outcomes, including Alzheimer's disease. Bariatric surgery has recently been shown to result in improved memory at 12-weeks postoperatively. However, the long-term effects of bariatric surgery on cognitive function remain unclear. DESIGN AND METHODS: Eighty-six individuals (63 bariatric surgery patients, 23 obese controls) were recruited from a prospective study examining the neurocognitive effects of bariatric surgery. All participants completed self-report measurements and a computerized cognitive test battery prior to surgery and at 12-week and 24-month follow-up; obese controls completed measures at equivalent time points. RESULTS: Bariatric surgery patients exhibited high rates of pre-operative cognitive impairments in attention, executive function, memory, and language. Relative to obese controls, repeated measures ANOVA showed improvements in memory from baseline to 12-weeks and 24-months postoperatively (P < 0.05). Regression analyses controlling for baseline factors revealed that a lower BMI at 24-months demonstrated a trend toward significance for improved memory (β = -.30, P = 0.075). CONCLUSION: These findings suggest that cognitive benefits of bariatric surgery may extend to 24-months postoperatively. Larger prospective studies with extended follow-up periods are needed to elucidate whether bariatric surgery decreases risk for cognitive decline and possibly the development of dementia.
OBJECTIVE:Obesity is as an independent risk factor for poor neurocognitive outcomes, including Alzheimer's disease. Bariatric surgery has recently been shown to result in improved memory at 12-weeks postoperatively. However, the long-term effects of bariatric surgery on cognitive function remain unclear. DESIGN AND METHODS: Eighty-six individuals (63 bariatric surgery patients, 23 obese controls) were recruited from a prospective study examining the neurocognitive effects of bariatric surgery. All participants completed self-report measurements and a computerized cognitive test battery prior to surgery and at 12-week and 24-month follow-up; obese controls completed measures at equivalent time points. RESULTS: Bariatric surgery patients exhibited high rates of pre-operative cognitive impairments in attention, executive function, memory, and language. Relative to obese controls, repeated measures ANOVA showed improvements in memory from baseline to 12-weeks and 24-months postoperatively (P < 0.05). Regression analyses controlling for baseline factors revealed that a lower BMI at 24-months demonstrated a trend toward significance for improved memory (β = -.30, P = 0.075). CONCLUSION: These findings suggest that cognitive benefits of bariatric surgery may extend to 24-months postoperatively. Larger prospective studies with extended follow-up periods are needed to elucidate whether bariatric surgery decreases risk for cognitive decline and possibly the development of dementia.
Authors: Robert H Paul; Jeffrey Lawrence; Leanne M Williams; C Clark Richard; Nicholas Cooper; Evian Gordon Journal: Int J Neurosci Date: 2005-11 Impact factor: 2.292
Authors: Miles Berger; Jacob W Nadler; Jeffrey Browndyke; Niccolo Terrando; Vikram Ponnusamy; Harvey Jay Cohen; Heather E Whitson; Joseph P Mathew Journal: Anesthesiol Clin Date: 2015-07-16
Authors: Rachel Galioto; Michael L Alosco; Mary Beth Spitznagel; Gladys Strain; Michael Devlin; Ronald Cohen; Ross D Crosby; James E Mitchell; John Gunstad Journal: J Clin Exp Neuropsychol Date: 2015-04-15 Impact factor: 2.475
Authors: Debra E Lyon; Ronald Cohen; Huaihou Chen; Debra L Kelly; Angela Starkweather; Hyo-Chol Ahn; Colleen K Jackson-Cook Journal: J Cancer Res Clin Oncol Date: 2016-04-21 Impact factor: 4.553
Authors: Jennifer M Walker; Shilpy Dixit; Anjelica C Saulsberry; James M May; Fiona E Harrison Journal: Neurobiol Dis Date: 2017-01-17 Impact factor: 5.996
Authors: Michael L Alosco; Rachel Galioto; Mary Beth Spitznagel; Gladys Strain; Michael Devlin; Ronald Cohen; Ross D Crosby; James E Mitchell; John Gunstad Journal: Am J Surg Date: 2013-10-10 Impact factor: 2.565