OBJECTIVE: To examine the utilization and outcomes of natural cycle (unstimulated) IVF as reported to the Society of Assisted Reproductive Technology (SART) in 2006 and 2007. DESIGN: Retrospective analysis. SETTING: Dataset analysis from the SART Clinical Outcome Reporting System national database. PATIENT(S): All patients undergoing IVF as reported to SART in 2006 and 2007. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Utilization of unstimulated IVF; description of patient demographics; and comparison of implantation and pregnancy rates between unstimulated and stimulated IVF cycles. RESULT(S): During 2006 and 2007 a total of 795 unstimulated IVF cycles were initiated. Success rates were age dependent, with patients <35 years of age demonstrating clinical pregnancy rates per cycle start, retrieval, and transfer of 19.2%, 26.8%, and 35.9%, respectively. Implantation rates were statistically higher for unstimulated compared with stimulated IVF in patients who were 35 to 42 years old. CONCLUSION(S): Unstimulated IVF represents <1% of the total IVF cycles initiated in the United States. The pregnancy and live birth rates per initiated cycle were 19.2% and 15.2%, respectively, in patients <35 years old. The implantation rates in unstimulated IVF cycles compared favorably to stimulated IVF. Natural cycle IVF may be considered in a wide range of patients as an alternative therapy for the infertile couple.
OBJECTIVE: To examine the utilization and outcomes of natural cycle (unstimulated) IVF as reported to the Society of Assisted Reproductive Technology (SART) in 2006 and 2007. DESIGN: Retrospective analysis. SETTING: Dataset analysis from the SART Clinical Outcome Reporting System national database. PATIENT(S): All patients undergoing IVF as reported to SART in 2006 and 2007. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Utilization of unstimulated IVF; description of patient demographics; and comparison of implantation and pregnancy rates between unstimulated and stimulated IVF cycles. RESULT(S): During 2006 and 2007 a total of 795 unstimulated IVF cycles were initiated. Success rates were age dependent, with patients <35 years of age demonstrating clinical pregnancy rates per cycle start, retrieval, and transfer of 19.2%, 26.8%, and 35.9%, respectively. Implantation rates were statistically higher for unstimulated compared with stimulated IVF in patients who were 35 to 42 years old. CONCLUSION(S): Unstimulated IVF represents <1% of the total IVF cycles initiated in the United States. The pregnancy and live birth rates per initiated cycle were 19.2% and 15.2%, respectively, in patients <35 years old. The implantation rates in unstimulated IVF cycles compared favorably to stimulated IVF. Natural cycle IVF may be considered in a wide range of patients as an alternative therapy for the infertile couple.
Authors: Talya Shaulov; Maria P Vélez; Karen Buzaglo; Simon J Phillips; Isaac Jacques Kadoch Journal: J Assist Reprod Genet Date: 2015-06-04 Impact factor: 3.412
Authors: Lori R Bernstein; Amelia C L Mackenzie; Se-Jin Lee; Charles L Chaffin; István Merchenthaler Journal: Endocrinology Date: 2015-12-29 Impact factor: 4.736
Authors: Zahraa Kollmann; Nick A Bersinger; Brett D McKinnon; Sophie Schneider; Michael D Mueller; Michael von Wolff Journal: Reprod Biol Endocrinol Date: 2015-03-24 Impact factor: 5.211
Authors: A J Bensdorp; R I Tjon-Kon-Fat; P M M Bossuyt; C A M Koks; G J E Oosterhuis; A Hoek; P G A Hompes; F J M Broekmans; H R Verhoeve; J P de Bruin; R van Golde; S Repping; B J Cohlen; M D A Lambers; P F van Bommel; E Slappendel; D Perquin; J M Smeenk; M J Pelinck; J Gianotten; D A Hoozemans; J W M Maas; M J C Eijkemans; F van der Veen; B W J Mol; M van Wely Journal: BMJ Date: 2015-01-09