| Literature DB >> 2362275 |
M L Edwards1, D M Stemerick, P S Sunkara.
Abstract
A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-pr open- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa cell test system. When evaluated in experimental tumor models in vivo, this compound exhibited antitumor activity against L1210 leukemia and B16 melanoma.Entities:
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Year: 1990 PMID： 2362275 DOI： 10.1021/jm00169a021
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446