Literature DB >> 23613701

A Case of Myopathy, Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS) Syndrome with Intracardiac Thrombus [corrected].

Jung-Chul Joo1, Myung Do Seol, Jin Won Yoon, Young Soo Lee, Dong-Keun Kim, Yong Hoon Choi, Hyo Seong Ahn, Wook Hyun Cho.   

Abstract

Myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a multisystem clinical syndrome manifested by mitochondrial myopathy, encephalopathy, lactic acidosis and recurrent stroke-like episodes. A 27-year-old female with MELAS syndrome presented with cerebral infarction. Echocardiography revealed a thrombus attached to the apex of the hypertrophied left ventricle, with decreased systolic function. The embolism of the intracardiac thrombus might have been the cause of stroke. There should be more consideration given to the increased possibility of intracardiac thrombus formation when a MELAS patient with cardiac involvement is encountered.

Entities:  

Keywords:  Heart; MELAS syndrome; Thrombosis

Year:  2013        PMID: 23613701      PMCID: PMC3629250          DOI: 10.4070/kcj.2013.43.3.204

Source DB:  PubMed          Journal:  Korean Circ J        ISSN: 1738-5520            Impact factor:   3.243


  10 in total

1.  Cardiac involvement in adults with m.3243A>G MELAS gene mutation.

Authors:  Tom C G Vydt; René F M de Coo; Osama I I Soliman; Folkert J Ten Cate; Robert-Jan M van Geuns; Wim B Vletter; Kees Schoonderwoerd; Bianca J C van den Bosch; Hubert J M Smeets; Marcel L Geleijnse
Journal:  Am J Cardiol       Date:  2006-11-29       Impact factor: 2.778

2.  A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.

Authors:  Y Goto; I Nonaka; S Horai
Journal:  Nature       Date:  1990-12-13       Impact factor: 49.962

3.  Diffusion-weighted image and MR spectroscopic analysis of a case of MELAS with repeated attacks.

Authors:  H S Kim; D I Kim; B I Lee; E K Jeong; C Choi; J D Lee; P H Yoon; E J Kim; S H Kim; Y K Yoon
Journal:  Yonsei Med J       Date:  2001-02       Impact factor: 2.759

4.  Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy.

Authors:  C W Lam; C H Lau; J C Williams; Y W Chan; L J Wong
Journal:  Eur J Pediatr       Date:  1997-07       Impact factor: 3.183

5.  Wolff-Parkinson-White syndrome in Patients With MELAS.

Authors:  Douglas M Sproule; Petra Kaufmann; Kristen Engelstad; Thomas J Starc; Allan J Hordof; Darryl C De Vivo
Journal:  Arch Neurol       Date:  2007-11

6.  Clinical features of A3243G mitochondrial tRNA mutation.

Authors:  Jong Hee Chae; Hee Hwang; Byung Chan Lim; Hae Il Cheong; Yong Seung Hwang; Ki Joong Kim
Journal:  Brain Dev       Date:  2004-10       Impact factor: 1.961

7.  A follow up study of myocardial involvement in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).

Authors:  Y Okajima; Y Tanabe; M Takayanagi; H Aotsuka
Journal:  Heart       Date:  1998-09       Impact factor: 5.994

8.  Successful treatment with succinate in a patient with MELAS.

Authors:  Hiroaki Oguro; Kenichi Iijima; Kazuo Takahashi; Atsushi Nagai; Hirokazu Bokura; Shuhei Yamaguchi; Shotai Kobayashi
Journal:  Intern Med       Date:  2004-05       Impact factor: 1.271

Review 9.  Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS): current concepts.

Authors:  M Hirano; S G Pavlakis
Journal:  J Child Neurol       Date:  1994-01       Impact factor: 1.987

10.  Decreased aminoacylation of mutant tRNAs in MELAS but not in MERRF patients.

Authors:  G V Börner; M Zeviani; V Tiranti; F Carrara; S Hoffmann; K D Gerbitz; H Lochmüller; D Pongratz; T Klopstock; A Melberg; E Holme; S Pääbo
Journal:  Hum Mol Genet       Date:  2000-03-01       Impact factor: 6.150

  10 in total

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