Literature DB >> 15206559

Successful treatment with succinate in a patient with MELAS.

Hiroaki Oguro1, Kenichi Iijima, Kazuo Takahashi, Atsushi Nagai, Hirokazu Bokura, Shuhei Yamaguchi, Shotai Kobayashi.   

Abstract

We present a case report of a 27-year-old man with MELAS, who presented with general convulsions and left flaccid hemiparesis. Anticonvulsant drugs failed to achieve complete control of his convulsions. A good response to oral administration of succinate has been maintained for more than 30 months, with no recurrence of any stroke-like episode. Succinate therapy may have potential for treatment of uncontrolled convulsive MELAS patients.

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Year:  2004        PMID： 15206559     DOI： 10.2169/internalmedicine.43.427

Source DB:  PubMed          Journal:  Intern Med        ISSN： 0918-2918            Impact factor:   1.271


  10 in total

Review 1.  The mitochondrial myopathy encephalopathy, lactic acidosis with stroke-like episodes (MELAS) syndrome: a review of treatment options.

Authors:  Fernando Scaglia; Jennifer L Northrop
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

2.  Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes.

Authors:  Ilkyun Im; Mi-Jin Jang; Seung Ju Park; Sang-Hee Lee; Jin-Ho Choi; Han-Wook Yoo; Seyun Kim; Yong-Mahn Han
Journal:  J Biol Chem       Date:  2015-10-21       Impact factor: 5.157

3.  A Case of Myopathy, Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS) Syndrome with Intracardiac Thrombus [corrected].

Authors:  Jung-Chul Joo; Myung Do Seol; Jin Won Yoon; Young Soo Lee; Dong-Keun Kim; Yong Hoon Choi; Hyo Seong Ahn; Wook Hyun Cho
Journal:  Korean Circ J       Date:  2013-03-31       Impact factor: 3.243

Review 4.  Liver disease in mitochondrial disorders.

Authors:  Way S Lee; Ronald J Sokol
Journal:  Semin Liver Dis       Date:  2007-08       Impact factor: 6.115

Review 5.  Treatment for mitochondrial disorders.

Authors:  Gerald Pfeffer; Kari Majamaa; Douglass M Turnbull; David Thorburn; Patrick F Chinnery
Journal:  Cochrane Database Syst Rev       Date:  2012-04-18

Review 6.  Diagnosis and treatment of mitochondrial myopathies.

Authors:  Gerald Pfeffer; Patrick F Chinnery
Journal:  Ann Med       Date:  2011-08-25       Impact factor: 4.709

Review 7.  Development of pharmacological strategies for mitochondrial disorders.

Authors:  M Kanabus; S J Heales; S Rahman
Journal:  Br J Pharmacol       Date:  2014-04       Impact factor: 8.739

8.  Childhood-Onset Progressive Dystonia With Mitochondrial DNA G14459A Mutation: Efficacy of Long-Term Sodium Succinate Treatment.

Authors:  Ayaka Koide; Hiroshi Ozawa; Masaya Kubota; Yuichi Goto
Journal:  Child Neurol Open       Date:  2014-11-10

9.  Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction.

Authors:  Abdelhakim Khellaf; Nuria Marco Garcia; Tamara Tajsic; Aftab Alam; Matthew G Stovell; Monica J Killen; Duncan J Howe; Mathew R Guilfoyle; Ibrahim Jalloh; Ivan Timofeev; Michael P Murphy; T Adrian Carpenter; David K Menon; Ari Ercole; Peter J Hutchinson; Keri Lh Carpenter; Eric P Thelin; Adel Helmy
Journal:  J Cereb Blood Flow Metab       Date:  2021-09-08       Impact factor: 6.200

10.  Succinate and the shortcut to the cure of metformin-induced lactic acidosis.

Authors:  Alessandro Protti
Journal:  Intensive Care Med Exp       Date:  2018-09-24
  10 in total

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