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Literature DB >> 23612712

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

Matthew A Inlay¹, Veronica Choe, Sophia Bharathi, Nathaniel B Fernhoff, James R Baker, Irving L Weissman, Seok Ki Choi.

Abstract

We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.

Entities: CellLine Chemical Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23612712 PMCID： PMC3926663 DOI： 10.1039/c3cc42179a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

23 in total

1. Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate.

Authors: Seok Ki Choi; Thommey Thomas; Ming-Hsin Li; Alina Kotlyar; Ankur Desai; James R Baker
Journal: Chem Commun (Camb) Date: 2010-02-06 Impact factor: 6.222

2. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

Authors: Yaroslava Ruzankina; Carolina Pinzon-Guzman; Amma Asare; Tony Ong; Laura Pontano; George Cotsarelis; Valerie P Zediak; Marielena Velez; Avinash Bhandoola; Eric J Brown
Journal: Cell Stem Cell Date: 2007-06-07 Impact factor: 24.633

3. Remotely activated protein-producing nanoparticles.

Authors: Avi Schroeder; Michael S Goldberg; Christian Kastrup; Yingxia Wang; Shan Jiang; Brian J Joseph; Christopher G Levins; Sneha T Kannan; Robert Langer; Daniel G Anderson
Journal: Nano Lett Date: 2012-05-08 Impact factor: 11.189

4. Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP.

Authors: Andrei V Karginov; Yan Zou; David Shirvanyants; Pradeep Kota; Nikolay V Dokholyan; Douglas D Young; Klaus M Hahn; Alexander Deiters
Journal: J Am Chem Soc Date: 2010-12-16 Impact factor: 15.419

5. A photochemical approach for controlled drug release in targeted drug delivery.

Authors: Seok Ki Choi; Manisha Verma; Justin Silpe; Ryan E Moody; Kenny Tang; Jeffrey J Hanson; James R Baker
Journal: Bioorg Med Chem Date: 2011-12-20 Impact factor: 3.641

6. Ligand-activated site-specific recombination in mice.

Authors: R Feil; J Brocard; B Mascrez; M LeMeur; D Metzger; P Chambon
Journal: Proc Natl Acad Sci U S A Date: 1996-10-01 Impact factor: 11.205

7. Photolabile precursors of glutamate: synthesis, photochemical properties, and activation of glutamate receptors on a microsecond time scale.

Authors: R Wieboldt; K R Gee; L Niu; D Ramesh; B K Carpenter; G P Hess
Journal: Proc Natl Acad Sci U S A Date: 1994-09-13 Impact factor: 11.205

8. Photolabile protecting groups for an acetylcholine receptor ligand. Synthesis and photochemistry of a new class of o-nitrobenzyl derivatives and their effects on receptor function.

Authors: J W Walker; J A McCray; G P Hess
Journal: Biochemistry Date: 1986-04-08 Impact factor: 3.162

9. A global double-fluorescent Cre reporter mouse.

Authors: Mandar Deepak Muzumdar; Bosiljka Tasic; Kazunari Miyamichi; Ling Li; Liqun Luo
Journal: Genesis Date: 2007-09 Impact factor: 2.487

10. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

Authors: D Metzger; J Clifford; H Chiba; P Chambon
Journal: Proc Natl Acad Sci U S A Date: 1995-07-18 Impact factor: 11.205

12 in total

1. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering.

Authors: Fuun Kawano; Risako Okazaki; Masayuki Yazawa; Moritoshi Sato
Journal: Nat Chem Biol Date: 2016-10-10 Impact factor: 15.040

2. A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging.

Authors: Pamela T Wong; Shengzhuang Tang; Jayme Cannon; Jhindan Mukherjee; Danielle Isham; Kristina Gam; Michael Payne; Sean A Yanik; James R Baker; Seok Ki Choi
Journal: Chembiochem Date: 2016-11-30 Impact factor: 3.164

3. A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing.

Authors: Kaiwen Ivy Liu; Muhammad Nadzim Bin Ramli; Cheok Wei Ariel Woo; Yuanming Wang; Tianyun Zhao; Xiujun Zhang; Guo Rong Daniel Yim; Bao Yi Chong; Ali Gowher; Mervyn Zi Hao Chua; Jonathan Jung; Jia Hui Jane Lee; Meng How Tan
Journal: Nat Chem Biol Date: 2016-09-12 Impact factor: 15.040

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

1. Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate.

2. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

3. Remotely activated protein-producing nanoparticles.

4. Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP.

5. A photochemical approach for controlled drug release in targeted drug delivery.

6. Ligand-activated site-specific recombination in mice.

7. Photolabile precursors of glutamate: synthesis, photochemical properties, and activation of glutamate receptors on a microsecond time scale.

8. Photolabile protecting groups for an acetylcholine receptor ligand. Synthesis and photochemistry of a new class of o-nitrobenzyl derivatives and their effects on receptor function.

9. A global double-fluorescent Cre reporter mouse.

10. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

1. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering.

2. A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging.

3. A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing.

4. Cyanine Photocages Enable Spatial Control of Inducible Cre-Mediated Recombination.

5. Optochemical Control of Bacterial Gene Expression: Novel Photocaged Compounds for Different Promoter Systems.

6. Genetically encoded optical activation of DNA recombination in human cells.

7. Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer.

8. Green-Light-Sensitive BODIPY Photoprotecting Groups for Amines.

9. A near-IR uncaging strategy based on cyanine photochemistry.

10. Switching Protein Localization by Site-Directed RNA Editing under Control of Light.