Scott D Halpern1, Richard D Hasz, Peter L Abt. 1. Perelman School of Medicine, University of Pennsylvania, 723 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. shalpern@exchange.upenn.edu
Abstract
RATIONALE: All U.S. acute care hospitals must maintain protocols for recovering organs from donors after circulatory determination of death (DCDD), but the numbers, types, and whereabouts of available organs are unknown. OBJECTIVES: To assess the maximal potential supply and distribution of DCDD organs in U.S. intensive care units. METHODS: We conducted a population-based cohort study among a randomly selected sample of 50 acute care hospitals in the highest-volume donor service area in the United States. We identified all potentially eligible donors dying within 90 minutes of the withdrawal of life-sustaining therapy from July 1, 2008 to June 30, 2009. MEASUREMENTS AND MAIN RESULTS: Using prespecified criteria, potential donors were categorized as optimal, suboptimal, or ineligible to donate their lungs, kidneys, pancreas, or liver. If only optimal DCDD organs were used, the deceased donor supplies of these organs could increase by up to 22.7, 8.9, 7.4, and 3.3%, respectively. If optimal and suboptimal DCDD organs were used, the corresponding supply increases could be up to 50.0, 19.7, 18.5, and 10.9%. Three-quarters of DCDD organs could be recovered from the 17.2% of hospitals with the highest annual donor volumes-typically those with trauma centers and more than 20 intensive care unit beds. CONCLUSIONS: Universal identification and referral of DCDD could increase the supply of transplantable lungs by up to one-half, and would not increase any other organ supply by more than one-fifth. The marked clustering of DCDD among a small number of identifiable hospitals could guide targeted interventions to improve DCDD identification, referral, and management.
RATIONALE: All U.S. acute care hospitals must maintain protocols for recovering organs from donors after circulatory determination of death (DCDD), but the numbers, types, and whereabouts of available organs are unknown. OBJECTIVES: To assess the maximal potential supply and distribution of DCDD organs in U.S. intensive care units. METHODS: We conducted a population-based cohort study among a randomly selected sample of 50 acute care hospitals in the highest-volume donor service area in the United States. We identified all potentially eligible donors dying within 90 minutes of the withdrawal of life-sustaining therapy from July 1, 2008 to June 30, 2009. MEASUREMENTS AND MAIN RESULTS: Using prespecified criteria, potential donors were categorized as optimal, suboptimal, or ineligible to donate their lungs, kidneys, pancreas, or liver. If only optimal DCDD organs were used, the deceased donor supplies of these organs could increase by up to 22.7, 8.9, 7.4, and 3.3%, respectively. If optimal and suboptimal DCDD organs were used, the corresponding supply increases could be up to 50.0, 19.7, 18.5, and 10.9%. Three-quarters of DCDD organs could be recovered from the 17.2% of hospitals with the highest annual donor volumes-typically those with trauma centers and more than 20 intensive care unit beds. CONCLUSIONS: Universal identification and referral of DCDD could increase the supply of transplantable lungs by up to one-half, and would not increase any other organ supply by more than one-fifth. The marked clustering of DCDD among a small number of identifiable hospitals could guide targeted interventions to improve DCDD identification, referral, and management.
Authors: Elizabeth M Sonnenberg; Jesse Y Hsu; Peter P Reese; David Goldberg; Peter L Abt Journal: Transplantation Date: 2019-10-21 Impact factor: 4.939
Authors: J J Mooney; H Hedlin; P K Mohabir; R Vazquez; J Nguyen; R Ha; P Chiu; K Patel; M R Zamora; D Weill; M R Nicolls; G S Dhillon Journal: Am J Transplant Date: 2016-02-04 Impact factor: 8.086