Comparison of the inhibition of deoxynivalenol and T-2 toxin on bovine and porcine platelet function.

A platelet model system has been used to investigate the inhibitory effects of deoxynivalenol (DON, vomitoxin) and T-2 toxin, alone and in combination. In both bovine and porcine systems, the most dramatic effect observed was the instability in the platelet aggregates formed in the presence of the mycotoxins. Bovine platelets were more sensitive to the inhibitory effects of both of the mycotoxins than porcine platelets and in both species T-2 toxin was a more effective platelet inhibitor than DON. The mycotoxins may inhibit platelet function by a similar mechanism since an additive inhibitory response was observed when DON and T-2 toxin were added together to platelet suspensions.