Literature DB >> 23604376

Effect of age on cytokine production in humans.

E D Bernstein, D M Murasko.   

Abstract

Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFNγ) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 studies in humans suggests that age-associated changes in cytokine production are not consistent.

Entities:  

Year:  1998        PMID： 23604376      PMCID： PMC3455461          DOI： 10.1007/s11357-998-0024-6

Source DB:  PubMed          Journal:  Age (Omaha)        ISSN： 0161-9152


  58 in total

1.  Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified Tac-positive T cells.

Authors:  S Negoro; H Hara; S Miyata; O Saiki; T Tanaka; K Yoshizaki; T Igarashi; S Kishimoto
Journal:  Mech Ageing Dev       Date:  1986-11-14       Impact factor: 5.432

2.  Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes.

Authors:  J E Nagel; R K Chopra; D C Powers; W H Adler
Journal:  Clin Exp Immunol       Date:  1989-02       Impact factor: 4.330

3.  Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents.

Authors:  S Castle; K Uyemura; W Wong; R Modlin; R Effros
Journal:  Mech Ageing Dev       Date:  1997-03       Impact factor: 5.432

4.  Polymorphism of age-related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL 2, IL 3 and IL 4.

Authors:  M Kubo; B Cinader
Journal:  Eur J Immunol       Date:  1990-06       Impact factor: 5.532

5.  Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation.

Authors:  H Hara; T Tanaka; S Negoro; Y Deguchi; S Nishio; O Saiki; S Kishimoto
Journal:  Mech Ageing Dev       Date:  1988-11-14       Impact factor: 5.432

6.  Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

Authors:  S Gillis; R Kozak; M Durante; M E Weksler
Journal:  J Clin Invest       Date:  1981-04       Impact factor: 14.808

7.  Age-related changes in the expression of IL-2 and high-affinity IL-2 binding sites.

Authors:  X Xu; I Beckman; J Bradley
Journal:  Int Arch Allergy Immunol       Date:  1993       Impact factor: 2.749

8.  The effect of influenza vaccination on IL2 production in healthy elderly: implications for current vaccination practices.

Authors:  J E McElhaney; G S Meneilly; B L Beattie; C D Helgason; S F Lee; R D Devine; R C Bleackley
Journal:  J Gerontol       Date:  1992-01

9.  Antitumoral properties of aged human monocytes.

Authors:  J A McLachlan; C D Serkin; K M Morrey; O Bakouche
Journal:  J Immunol       Date:  1995-01-15       Impact factor: 5.422

10.  Dysregulation between TH1 and TH2 T cell subpopulations in the elderly.

Authors:  I Cakman; J Rohwer; R M Schütz; H Kirchner; L Rink
Journal:  Mech Ageing Dev       Date:  1996-06-25       Impact factor: 5.432
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  10 in total

1.  Rapamycin Prolongs Graft Survival and Induces CD4+IFN-γ+IL-10+ Regulatory Type 1 Cells in Old Recipient Mice.

Authors:  Markus Quante; Timm Heinbokel; Karoline Edtinger; Koichiro Minami; Hirofumi Uehara; Yeqi Nian; Haruhito Azuma; Reza Abdi; Abdallah Elkhal; Stefan G Tullius
Journal:  Transplantation       Date:  2018-01       Impact factor: 4.939

2.  Mechanistic insights into the impairment of memory B cells and antibody production in the elderly.

Authors:  Judith H Aberle; Karin Stiasny; Michael Kundi; Franz X Heinz
Journal:  Age (Dordr)       Date:  2012-01-27

Review 3.  A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling.

Authors:  Ainhoa Arana Echarri; Mark Beresford; John P Campbell; Robert H Jones; Rachel Butler; Kenneth J Gollob; Patricia C Brum; Dylan Thompson; James E Turner
Journal:  Front Immunol       Date:  2021-02-01       Impact factor: 7.561

4.  Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Authors:  Rob Ter Horst; Martin Jaeger; Sanne P Smeekens; Marije Oosting; Morris A Swertz; Yang Li; Vinod Kumar; Dimitri A Diavatopoulos; Anne F M Jansen; Heidi Lemmers; Helga Toenhake-Dijkstra; Antonius E van Herwaarden; Matthijs Janssen; Renate G van der Molen; Irma Joosten; Fred C G J Sweep; Johannes W Smit; Romana T Netea-Maier; Mieke M J F Koenders; Ramnik J Xavier; Jos W M van der Meer; Charles A Dinarello; Norman Pavelka; Cisca Wijmenga; Richard A Notebaart; Leo A B Joosten; Mihai G Netea
Journal:  Cell       Date:  2016-11-03       Impact factor: 41.582

5.  Effect of age on chronic inflammation and responsiveness to bacterial and viral challenges.

Authors:  Ingrid Elisia; Vivian Lam; Elyse Hofs; Michael Yu Li; Mariah Hay; Brandon Cho; Angela Brooks-Wilson; Miriam Rosin; Luke Bu; William Jia; Gerald Krystal
Journal:  PLoS One       Date:  2017-11-29       Impact factor: 3.240

6.  Serum Levels of Il-12 and Il-23 in Breast Cancer Patients Infected with Toxoplasma gondii: A Case-Control Study.

Authors:  Maha Mustafa Assim; Entsar Jabbar Saheb
Journal:  Iran J Parasitol       Date:  2020 Oct-Dec       Impact factor: 1.012

7.  Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.

Authors:  Kinga K Smolen; Alec L Plotkin; Casey P Shannon; Olubukola T Idoko; Jensen Pak; Alansana Darboe; Simon van Haren; Nelly Amenyogbe; Scott J Tebbutt; Tobias R Kollmann; Beate Kampmann; Al Ozonoff; Ofer Levy; Oludare A Odumade
Journal:  Cytokine       Date:  2021-09-28       Impact factor: 3.861

8.  Toxoplasma gondii infection and peripheral-blood gene expression profiling of older people reveals dysregulation of cytokines and identifies hub genes as potential therapeutic targets.

Authors:  Carlos A Naranjo-Galvis; Kelly Y Cardona-Londoño; Mary Orrego-Cardozo; Xabier Elcoroaristizabal-Martín
Journal:  Heliyon       Date:  2022-09-08

9.  CTLA4-Ig prolongs graft survival specifically in young but not old mice.

Authors:  Timm Heinbokel; Markus Quante; Jasper Iske; Yeqi Nian; Ryoichi Maenosono; Koichiro Minami; Yang Liu; Haruhito Azuma; Abdallah Elkhal; Stefan G Tullius
Journal:  Am J Transplant       Date:  2020-09-03       Impact factor: 8.086

10.  Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time.

Authors:  M Weckmann; D Thiele; L Liboschik; T Bahmer; M Pech; A-M Dittrich; O Fuchs; C Happle; B Schaub; I Ricklefs; K F Rabe; E von Mutius; G Hansen; I R König; M V Kopp
Journal:  Clin Exp Immunol       Date:  2020-12-15       Impact factor: 5.732
  10 in total

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