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Literature DB >> 23603317

Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments.

Anastasiya Yermakova¹, Nicholas J Mantis.

Abstract

SylH3 and 24B11 are murine monoclonal antibodies directed against different epitopes on ricin toxin's binding (RTB) subunit that have been shown to passively protect mice against ricin challenge. Here we report that Fab fragments of SylH3 and 24B11 neutralize ricin in a cell based assay, and in a mouse challenge model as effectively as their respective full length parental IgGs. These data demonstrate that immunity to ricin can occur independent of Fc-mediated clearance.

Entities: Chemical Disease Gene Species

Keywords: Biodefense; Mouse; Neutralizing antibodies; Toxin

Mesh：

Substances：

Year: 2013 PMID： 23603317 PMCID： PMC3774546 DOI： 10.1016/j.toxicon.2013.04.005

Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033

34 in total

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Authors: R G A Jones; T-A Alsop; R Hull; R Tierney; P Rigsby; J Holley; D Sesardic
Journal: Toxicon Date: 2006-06-14 Impact factor: 3.033

2. Pharmacokinetics of heterologous and homologous immunoglobulin G, F(ab')2 and Fab after intravenous administration in the rat.

Authors: M I Bazin-Redureau; C B Renard; J M Scherrmann
Journal: J Pharm Pharmacol Date: 1997-03 Impact factor: 3.765

3. Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity.

Authors: Laura Vitale; Diann Blanset; Israel Lowy; Thomas O'Neill; Joel Goldstein; Stephen F Little; Gerard P Andrews; Gary Dorough; Ronald K Taylor; Tibor Keler
Journal: Infect Immun Date: 2006-10 Impact factor: 3.441

4. Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit.

Authors: Carolyn R McGuinness; Nicholas J Mantis
Journal: Infect Immun Date: 2006-06 Impact factor: 3.441

5. Analysis of the Fc gamma receptor-dependent component of neutralization measured by anthrax toxin neutralization assays.

Authors: Anita Verma; Miriam M Ngundi; Bruce D Meade; Roberto De Pascalis; Karen L Elkins; Drusilla L Burns
Journal: Clin Vaccine Immunol Date: 2009-08-05

6. A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin.

Authors: Lori M Neal; Joanne O'Hara; Robert N Brey; Nicholas J Mantis
Journal: Infect Immun Date: 2009-10-26 Impact factor: 3.441

7. Beta 2-microglobulin deficient mice catabolize IgG more rapidly than FcRn- alpha-chain deficient mice.

Authors: Jonghan Kim; C L Bronson; Manzoor A Wani; Tatiana M Oberyszyn; Sudhasri Mohanty; Chaity Chaudhury; William L Hayton; John M Robinson; Clark L Anderson
Journal: Exp Biol Med (Maywood) Date: 2008-03-28

Review 8. Pharmacokinetic aspects of digoxin-specific Fab therapy in the management of digitalis toxicity.

Authors: M R Ujhelyi; S Robert
Journal: Clin Pharmacokinet Date: 1995-06 Impact factor: 6.447

9. Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors.

Authors: Eric T Harvill; Manuel Osorio; Crystal L Loving; Gloria M Lee; Vanessa K Kelly; Tod J Merkel
Journal: Infect Immun Date: 2008-03-03 Impact factor: 3.441

10. Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model.

Authors: James K Roche; Matthew K Stone; Lisa K Gross; Matthew Lindner; Regina Seaner; Seth H Pincus; Tom G Obrig
Journal: Lab Invest Date: 2008-09-08 Impact factor: 5.662

9 in total

1. Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.

Authors: David J Vance; Jacqueline M Tremblay; Nicholas J Mantis; Charles B Shoemaker
Journal: J Biol Chem Date: 2013-11-07 Impact factor: 5.157

2. Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro.

Authors: Joanne M O'Hara; Nicholas J Mantis
Journal: J Immunol Methods Date: 2013-06-15 Impact factor: 2.303

Review 3. Progress and challenges associated with the development of ricin toxin subunit vaccines.

Authors: David J Vance; Nicholas J Mantis
Journal: Expert Rev Vaccines Date: 2016-04-06 Impact factor: 5.217

4. An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation.

Authors: Yinghui Rong; Fernando J Torres-Velez; Dylan Ehrbar; Jennifer Doering; Renjie Song; Nicholas J Mantis
Journal: Hum Vaccin Immunother Date: 2019-10-29 Impact factor: 3.452

9. Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

Authors: Cristina Herrera; David J Vance; Leslie E Eisele; Charles B Shoemaker; Nicholas J Mantis
Journal: PLoS One Date: 2014-06-11 Impact factor: 3.240