Literature DB >> 2360

The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets.

D J Boullin, R P Grimes, M W Orr.   

Abstract

The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.

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Year:  1975        PMID： 2360      PMCID： PMC1666734          DOI： 10.1111/j.1476-5381.1975.tb07432.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  The comparative pharmacology of flupenthixol and some reference neuroleptics.

Authors:  I M Nielsen; V Pedersen; M Nymark; K F Franck; V Boeck; B Fjalland; A V Christensen
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1973

2.  On flupentixol, an antidepressant of a new chemical group.

Authors:  P J Reiter
Journal:  Br J Psychiatry       Date:  1969-12       Impact factor: 9.319

3.  Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.

Authors:  D J Boullin; H F Woods; R P Grimes; D G Grahame-Smith
Journal:  Br J Clin Pharmacol       Date:  1975-02       Impact factor: 4.335

4.  Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.

Authors:  D J Boullin; D G Grahame-Smith; R P Grimes; H F Woods
Journal:  Br J Pharmacol       Date:  1975-01       Impact factor: 8.739

5.  Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-DOPA.

Authors:  D J Boullin; R A O'Brien
Journal:  Br J Pharmacol       Date:  1970-08       Impact factor: 8.739

6.  Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.

Authors:  G V Born; K Juengjaroen; F Michal
Journal:  Br J Pharmacol       Date:  1972-01       Impact factor: 8.739

7.  The mechanism of adenosine diphosphate induced platelet aggregation: binding to platelet receptors and inhibition of binding and aggregation by prostaglandin E 1 .

Authors:  D J Boullin; A R Green; K S Price
Journal:  J Physiol       Date:  1972-03       Impact factor: 5.182
  7 in total
  2 in total

1.  Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats.

Authors:  H Y Meltzer; S M Paul; V S Fang
Journal:  Psychopharmacology (Berl)       Date:  1977-01-31       Impact factor: 4.530

2.  The ralationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine.

Authors:  M W Orr; D J Boullin
Journal:  Br J Clin Pharmacol       Date:  1976-10       Impact factor: 4.335
  2 in total

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