Literature DB >> 14352

Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats.

H Y Meltzer, S M Paul, V S Fang.   

Abstract

Cis (alpha)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (beta)-flupenthixol and (-)-butaclamol are not. alpha-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the beta-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.

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Year:  1977        PMID： 14352     DOI： 10.1007/BF00431737

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  19 in total

1.  Clozapine increases rat serum prolactin levels.

Authors:  H Y Meltzer; S Daniels; V S Fang
Journal:  Life Sci       Date:  1975-08-01       Impact factor: 5.037

2.  Dopamine receptor binding in the corpus striatum of mammalian brain.

Authors:  D R Burt; S J Enna; I Creese; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

3.  Effect of butaclamol and its enantiomers upon striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats.

Authors:  W Lippmann; T Pugsley; J Merker
Journal:  Life Sci       Date:  1975-01-15       Impact factor: 5.037

4.  Effect of butaclamol on dopamine-sensitive adenylate cyclase in the rat striatum.

Authors:  R J Miller; A S Horn; L L Iversen
Journal:  J Pharm Pharmacol       Date:  1975-03       Impact factor: 3.765

5.  Butaclamol hydrochloride in newly admitted schizophrenics.

Authors:  L E Hollister; K L Davis; P A Berger
Journal:  Psychopharmacol Commun       Date:  1975

6.  The comparative pharmacology of flupenthixol and some reference neuroleptics.

Authors:  I M Nielsen; V Pedersen; M Nymark; K F Franck; V Boeck; B Fjalland; A V Christensen
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1973

7.  Inhibition of rat prolactin release by apomorphine in vivo and in vitro.

Authors:  E B Smalstig; B D Sawyer; J A Clemens
Journal:  Endocrinology       Date:  1974-07       Impact factor: 4.736

8.  Butaclamol hydrochloride (AY-23,028): an early evaluation in severely ill schizophrenics.

Authors:  D H Mielke; D M Gallant; T Oelsner; C M Kessler; W K Tomlinson; G H Cohen
Journal:  Dis Nerv Syst       Date:  1975-01

9.  The effect of neuroleptics on serum prolactin in schizophrenic patients.

Authors:  H Y Meltzer; V S Fang
Journal:  Arch Gen Psychiatry       Date:  1976-03

10.  Dopamine receptor binding: differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidol.

Authors:  I Creese; D R Burt; S H Snyder
Journal:  Life Sci       Date:  1975-09-15       Impact factor: 5.037
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  4 in total

1.  Prolactin releasing effect of sulpiride isomers in rats and man.

Authors:  E E Müller; E Stefanini; F Camanni; V Locatelli; F Massara; P F Spano; D Cocchi
Journal:  J Neural Transm       Date:  1979       Impact factor: 3.575

2.  alpha-Flupenthixol: an antagonist of dopamine-evoked fluid secretion by an insect salivary gland preparation.

Authors:  J Breward; C R House; R K Smith
Journal:  Br J Pharmacol       Date:  1980-05       Impact factor: 8.739

Review 3.  Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications.

Authors:  E E Müller; V Locatelli; S Cella; A Peñalva; A Novelli; D Cocchi
Journal:  Drugs       Date:  1983-04       Impact factor: 9.546

4.  Perlapine: relationship between stimulation of prolactin secretion and antipsychotic activity.

Authors:  H Y Meltzer; R G Fessler; V S Fang
Journal:  Psychopharmacology (Berl)       Date:  1977-10-20       Impact factor: 4.530
  4 in total

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