BACKGROUND:High-strength static magnetic field stimulation (SMS) results in a period of reduced corticomotor excitability that may be mediated through a decrease in membrane excitability. OBJECTIVE: As resting motor threshold (RMT) is thought to reflect membrane excitability, we hypothesized that SMS may increase RMT and that there would be an inverse relationship between RMT and motor-evoked potential (MEP) amplitude. METHODS:Ten healthy subjects (aged 20-29; 4 females) participated in a double-blinded crossover design comparing MEP amplitude and RMT before and after a 15-min period of SMS or sham stimulation over primary motor cortex (M1). RESULTS:MEP amplitude was initially significantly reduced post-SMS (∼20%), and returned to baseline by 6 min post-intervention. MEP amplitude and RMT were inversely correlated (r(2) = 0.924; P = 0.001). Sham stimulation had no effect on MEP amplitude (P = 0.969) or RMT (P = 0.549). CONCLUSION: After SMS, corticomotor excitability is transiently reduced in association with a correlated modulation of RMT. SMS after effects may be mediated in part by a reduction in membrane excitability, suggesting a possible role for non-synaptic (intrinsic) plasticity mechanisms.
RCT Entities:
BACKGROUND: High-strength static magnetic field stimulation (SMS) results in a period of reduced corticomotor excitability that may be mediated through a decrease in membrane excitability. OBJECTIVE: As resting motor threshold (RMT) is thought to reflect membrane excitability, we hypothesized that SMS may increase RMT and that there would be an inverse relationship between RMT and motor-evoked potential (MEP) amplitude. METHODS: Ten healthy subjects (aged 20-29; 4 females) participated in a double-blinded crossover design comparing MEP amplitude and RMT before and after a 15-min period of SMS or sham stimulation over primary motor cortex (M1). RESULTS: MEP amplitude was initially significantly reduced post-SMS (∼20%), and returned to baseline by 6 min post-intervention. MEP amplitude and RMT were inversely correlated (r(2) = 0.924; P = 0.001). Sham stimulation had no effect on MEP amplitude (P = 0.969) or RMT (P = 0.549). CONCLUSION: After SMS, corticomotor excitability is transiently reduced in association with a correlated modulation of RMT. SMS after effects may be mediated in part by a reduction in membrane excitability, suggesting a possible role for non-synaptic (intrinsic) plasticity mechanisms.
Authors: Carmen Carrasco-López; Vanesa Soto-León; Virginia Céspedes; Paolo Profice; Bryan A Strange; Guglielmo Foffani; Antonio Oliviero Journal: J Neurosci Date: 2017-03-09 Impact factor: 6.167
Authors: Vanesa Soto-León; Mabel Torres-Llacsa; Laura Mordillo-Mateos; Carmen Carrasco-López; José A Pineda-Pardo; Ana I Velasco; Laura Abad-Toribio; Jesús Tornero; Guglielmo Foffani; Bryan A Strange; Antonio Oliviero Journal: Sci Rep Date: 2022-05-12 Impact factor: 4.996
Authors: Ankshita Prasad; Daniel B Loong Teh; Agata Blasiak; Chou Chai; Yang Wu; Payam M Gharibani; In Hong Yang; Thang T Phan; Kah Leong Lim; Hyunsoo Yang; Xiaogang Liu; Angelo H All Journal: Sci Rep Date: 2017-07-27 Impact factor: 4.379
Authors: M Dileone; M C Carrasco-López; J C Segundo-Rodriguez; L Mordillo-Mateos; N López-Ariztegui; F Alonso-Frech; M J Catalan-Alonso; J A Obeso; A Oliviero; G Foffani Journal: Sci Rep Date: 2017-06-28 Impact factor: 4.379