Literature DB >> 23595999

Histone H4 lysine 16 acetylated isoform synthesis opens new route to biophysical studies.

Tej K Pandita1.   

Abstract

Histone H4 lysine acetylation regulated by MOF (males absent on the first) was initially discovered as a dosage compensation epigenetic mark. Recent studies have revealed, however, that the epigenetic mark has a critical role in cellular function both during oogenesis as well as oncogenesis. Detailed molecular analysis of H4K16 isoforms and other posttranslational modified histones has been limited by the lack of means to prepare sufficient material for in vitro study. This paper describes an improved method to prepare acetylated H4K16 as well as other covalently modified histone H4 isoform for biophysical studies.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23595999      PMCID： PMC4151460          DOI： 10.1002/pmic.201300145

Source DB:  PubMed          Journal:  Proteomics        ISSN： 1615-9853            Impact factor:   3.984


  23 in total

1.  30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction.

Authors:  Philip J J Robinson; Woojin An; Andrew Routh; Fabrizio Martino; Lynda Chapman; Robert G Roeder; Daniela Rhodes
Journal:  J Mol Biol       Date:  2008-04-29       Impact factor: 5.469

2.  MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

Authors:  Girdhar G Sharma; Sairei So; Arun Gupta; Rakesh Kumar; Christelle Cayrou; Nikita Avvakumov; Utpal Bhadra; Raj K Pandita; Matthew H Porteus; David J Chen; Jacques Cote; Tej K Pandita
Journal:  Mol Cell Biol       Date:  2010-05-17       Impact factor: 4.272

3.  Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.

Authors:  Vaidehi Krishnan; Maggie Zi Ying Chow; Zimei Wang; Le Zhang; Baohua Liu; Xinguang Liu; Zhongjun Zhou
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-11       Impact factor: 11.205

4.  Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.

Authors:  Mario F Fraga; Esteban Ballestar; Ana Villar-Garea; Manuel Boix-Chornet; Jesus Espada; Gunnar Schotta; Tiziana Bonaldi; Claire Haydon; Santiago Ropero; Kevin Petrie; N Gopalakrishna Iyer; Alberto Pérez-Rosado; Enrique Calvo; Juan A Lopez; Amparo Cano; Maria J Calasanz; Dolors Colomer; Miguel Angel Piris; Natalie Ahn; Axel Imhof; Carlos Caldas; Thomas Jenuwein; Manel Esteller
Journal:  Nat Genet       Date:  2005-03-13       Impact factor: 38.330

5.  Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.

Authors:  Rakesh Kumar; Clayton R Hunt; Arun Gupta; Suraj Nannepaga; Raj K Pandita; Jerry W Shay; Robert Bachoo; Thomas Ludwig; Dennis K Burns; Tej K Pandita
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-14       Impact factor: 11.205

6.  T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.

Authors:  Arun Gupta; Clayton R Hunt; Raj K Pandita; Juhee Pae; K Komal; Mayank Singh; Jerry W Shay; Rakesh Kumar; Kiyoshi Ariizumi; Nobuo Horikoshi; Walter N Hittelman; Chandan Guha; Thomas Ludwig; Tej K Pandita
Journal:  Mutagenesis       Date:  2013-02-05       Impact factor: 3.000

Review 7.  Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.

Authors:  Clayton R Hunt; Deepti Ramnarain; Nobuo Horikoshi; Puneeth Iyengar; Raj K Pandita; Jerry W Shay; Tej K Pandita
Journal:  Radiat Res       Date:  2013-02-01       Impact factor: 2.841

8.  Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.

Authors:  Priya Kapoor-Vazirani; Jacob D Kagey; Doris R Powell; Paula M Vertino
Journal:  Cancer Res       Date:  2008-08-15       Impact factor: 12.701

9.  The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma.

Authors:  Stefan Pfister; Stephen Rea; Mikko Taipale; Frank Mendrzyk; Beate Straub; Carina Ittrich; Olaf Thuerigen; Hans Peter Sinn; Asifa Akhtar; Peter Lichter
Journal:  Int J Cancer       Date:  2008-03-15       Impact factor: 7.396

10.  Distinct contributions of MSL complex subunits to the transcriptional enhancement responsible for dosage compensation in Drosophila.

Authors:  David Dunlap; Ruth Yokoyama; Huiping Ling; He-Ying Sun; Kerry McGill; Simona Cugusi; John C Lucchesi
Journal:  Nucleic Acids Res       Date:  2012-10-09       Impact factor: 16.971
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  5 in total

1.  MOF Suppresses Replication Stress and Contributes to Resolution of Stalled Replication Forks.

Authors:  Dharmendra Kumar Singh; Raj K Pandita; Mayank Singh; Sharmistha Chakraborty; Shashank Hambarde; Deepti Ramnarain; Vijaya Charaka; Kazi Mokim Ahmed; Clayton R Hunt; Tej K Pandita
Journal:  Mol Cell Biol       Date:  2018-02-27       Impact factor: 4.272

Review 2.  A multifaceted role for MOF histone modifying factor in genome maintenance.

Authors:  Kalpana Mujoo; Clayton R Hunt; Nobuo Horikoshi; Tej K Pandita
Journal:  Mech Ageing Dev       Date:  2016-03-30       Impact factor: 5.432

3.  More complex transcriptional regulation and stress response by MOF.

Authors:  N Horikoshi; C R Hunt; T K Pandita
Journal:  Oncogene       Date:  2015-10-05       Impact factor: 8.756

4.  The Non-Specific Lethal (NSL) Histone Acetyltransferase Complex Transcriptionally Regulates Yin Yang 1-Mediated Cell Proliferation in Human Cells.

Authors:  Hongsen Liu; Tao Wei; Lin Sun; Tingting Wu; Fuqiang Li; Jianlei Zhao; Jinmeng Chu; Fei Wang; Yong Cai; Jingji Jin
Journal:  Int J Mol Sci       Date:  2022-03-30       Impact factor: 6.208

5.  Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.

Authors:  Kalpana Mujoo; Raj K Pandita; Anjana Tiwari; Vijay Charaka; Sharmistha Chakraborty; Dharmendra Kumar Singh; Shashank Hambarde; Walter N Hittelman; Nobuo Horikoshi; Clayton R Hunt; Kum Kum Khanna; Alexander Y Kots; E Brian Butler; Ferid Murad; Tej K Pandita
Journal:  Stem Cell Reports       Date:  2017-11-02       Impact factor: 7.765
  5 in total

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