BACKGROUND: Congenital and acquired tracheal stenosis continues to be challenging problems. The purpose of this study was to evaluate the efficacy of an asymmetrically porous membrane (APM) to induce tracheal reconstruction by inhibition of granulation tissue growth into the tracheal lumen whereas minimizing graft failure. METHODS: The APM was fabricated with polycaprolactone (PCL) and pluronic F127 to have nano-size pores at top side, whereas the bottom side had micro-size pores. Fifteen rabbits underwent tracheal defect, which was then reconstructed with the APM. Rabbits were euthanized 1, 4, and 12 weeks postoperatively, and endoscopic, histologic, and radiologic evaluations were conducted. RESULTS: Endoscopy did not reveal granulation ingrowth into tracheal lumen. APM was well incorporated into the surrounding tissue on histologic evaluation. CT scans showed well maintained airways. CONCLUSION: Off-the-shelf use of APM for tracheal reconstruction seems to be a promising strategy in the treatment of tracheal defects.
BACKGROUND: Congenital and acquired tracheal stenosis continues to be challenging problems. The purpose of this study was to evaluate the efficacy of an asymmetrically porous membrane (APM) to induce tracheal reconstruction by inhibition of granulation tissue growth into the tracheal lumen whereas minimizing graft failure. METHODS: The APM was fabricated with polycaprolactone (PCL) and pluronic F127 to have nano-size pores at top side, whereas the bottom side had micro-size pores. Fifteen rabbits underwent tracheal defect, which was then reconstructed with the APM. Rabbits were euthanized 1, 4, and 12 weeks postoperatively, and endoscopic, histologic, and radiologic evaluations were conducted. RESULTS: Endoscopy did not reveal granulation ingrowth into tracheal lumen. APM was well incorporated into the surrounding tissue on histologic evaluation. CT scans showed well maintained airways. CONCLUSION: Off-the-shelf use of APM for tracheal reconstruction seems to be a promising strategy in the treatment of tracheal defects.
Authors: Yanchun Liu; Tyler Nelson; Jason Chakroff; Barrett Cromeens; Jed Johnson; John Lannutti; Gail E Besner Journal: J Biomed Mater Res B Appl Biomater Date: 2018-09-30 Impact factor: 3.368
Authors: Ji Suk Choi; Min Sang Lee; Jooyoung Kim; Min Rye Eom; Eun Ji Jeong; Minhyung Lee; Su A Park; Ji Hoon Jeong; Seong Keun Kwon Journal: Tissue Eng Regen Med Date: 2021-03-25 Impact factor: 4.169
Authors: Alan Is Morais; Xichi Wang; Ewerton G Vieira; Bartolomeu C Viana; Edson C Silva-Filho; Josy A Osajima; Samson Afewerki; Marcus Af Corat; Heurison S Silva; Fernanda R Marciano; Guillermo U Ruiz-Esparza; Thiago D Stocco; Mirian Mm de Paula; Anderson O Lobo Journal: Int J Nanomedicine Date: 2020-02-19