BACKGROUND: This study compared the risk of fatal cerebrovascular accidents (CVAs) in patients with early-stage glottic laryngeal cancer receiving surgery or external beam radiation therapy (EBRT). METHODS: Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early-stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; p = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04-2.96; p = .037). CONCLUSION: Treatment for early-stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery.
BACKGROUND: This study compared the risk of fatal cerebrovascular accidents (CVAs) in patients with early-stage glottic laryngeal cancer receiving surgery or external beam radiation therapy (EBRT). METHODS: Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early-stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; p = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04-2.96; p = .037). CONCLUSION: Treatment for early-stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery.
Authors: Andrea Gallo; Marco de Vincentiis; Valentina Manciocco; Marilia Simonelli; Maria Luisa Fiorella; Jatin P Shah Journal: Laryngoscope Date: 2002-02 Impact factor: 3.325
Authors: Lucille D A Dorresteijn; Arnoud C Kappelle; Willem Boogerd; Willem J Klokman; Alfons J M Balm; Ronald B Keus; Flora E van Leeuwen; Harry Bartelink Journal: J Clin Oncol Date: 2002-01-01 Impact factor: 44.544
Authors: David G Grant; John R Salassa; Michael L Hinni; Bruce W Pearson; Richard E Hayden; William C Perry Journal: Otolaryngol Head Neck Surg Date: 2007-09 Impact factor: 3.497
Authors: Mikel Sadek; Neal S Cayne; Hyun J Shin; Irene C Turnbull; Michael L Marin; Peter L Faries Journal: J Vasc Surg Date: 2009-08-22 Impact factor: 4.268
Authors: Jaclyn L F Bosco; Rebecca A Silliman; Soe Soe Thwin; Ann M Geiger; Diana S M Buist; Marianne N Prout; Marianne Ulcickas Yood; Reina Haque; Feifei Wei; Timothy L Lash Journal: J Clin Epidemiol Date: 2009-05-19 Impact factor: 6.437
Authors: Jeffrey C Haynes; Mitchell Machtay; Randal S Weber; Gregory S Weinstein; Ara A Chalian; David I Rosenthal Journal: Laryngoscope Date: 2002-10 Impact factor: 3.325
Authors: Grace L Smith; Benjamin D Smith; Thomas A Buchholz; Sharon H Giordano; Adam S Garden; Wendy A Woodward; Harlan M Krumholz; Randal S Weber; K-Kian Ang; David I Rosenthal Journal: J Clin Oncol Date: 2008-08-25 Impact factor: 44.544
Authors: David J Carpenter; Yvonne M Mowery; Gloria Broadwater; Anna Rodrigues; Amy J Wisdom; Jennifer A Dorth; Pretesh R Patel; Cynthia K Shortell; Robert Clough; David M Brizel Journal: Oral Oncol Date: 2018-03-14 Impact factor: 5.337
Authors: K Garcez; C C Lim; P Whitehurst; D Thomson; K F Ho; M Lowe; A Sykes; L W Lee; B Yap; N Slevin Journal: Br J Radiol Date: 2014-02-17 Impact factor: 3.039
Authors: Jared Gershowitz; Hann-Hsiang Chao; Abigail Doucette; John N Lukens; Samuel Swisher-McClure; Gregory S Weinstein; Bert W O'Malley; Ara A Chalian; Christopher H Rassekh; Jason G Newman; Roger B Cohen; Joshua M Bauml; Charu Aggarwal; Alexander Lin Journal: Br J Radiol Date: 2019-10-15 Impact factor: 3.039
Authors: Alexander Lin; John H C Chang; Ryan S Grover; Frank J P Hoebers; Upendra Parvathaneni; Samir H Patel; Juliette Thariat; David J Thomson; Johannes A Langendijk; Steven J Frank Journal: Int J Part Ther Date: 2021-06-25