| Literature DB >> 23595744 |
Arie Reijerkerk1, M Alejandro Lopez-Ramirez, Bert van Het Hof, Joost A R Drexhage, Wouter W Kamphuis, Gijs Kooij, Joost B Vos, Tineke C T M van der Pouw Kraan, Anton J van Zonneveld, Anton J Horrevoets, Alexandre Prat, Ignacio A Romero, Helga E de Vries.
Abstract
Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.Entities:
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Year: 2013 PMID： 23595744 PMCID： PMC6618888 DOI： 10.1523/JNEUROSCI.3965-12.2013
Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167