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Literature DB >> 27844280

Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation.

Mohammad Hossein Geranmayeh^1,2,3, Alireza Nourazarian^2,4, Çığır Biray Avci⁵, Reza Rahbarghazi^6,7, Mehdi Farhoudi⁸.

Abstract

Establishing systemic therapeutics for neuro-inflammatory diseases is a main objective of regenerative medicine, certainly focusing on restoration of BBB dysfunction and neurovascular reconstitution. In this context, the regenerative capacity and therapeutic effects of different stem cells have been recently found to bring hopeful outcomes through trans-differentiation, paracrine interactions, and molecular cross-talk of transplanted stem cells with resident cells of blood-brain barrier. Here, we highlight some of the most recent scientific breakthroughs and discoveries by different authorities. Potency of different types of stem cells on the regulation and maintenance of endothelial and perivascular cells via various microRNAs was also studied.

Entities: Disease

Keywords: Brain neurovascular unit; MicroRNAs; Paracrine behavior; Stem cell; Trans-differentiation

Mesh：

Year: 2016 PMID： 27844280 DOI： 10.1007/s12035-016-0286-4

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590

163 in total

1. Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema.

Authors: Chun Fu Lien; Sarajo Kumar Mohanta; Malgorzata Frontczak-Baniewicz; Jerome D Swinny; Barbara Zablocka; Dariusz C Górecki
Journal: J Biol Chem Date: 2012-10-05 Impact factor: 5.157

2. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.

Authors: Matthew J Stebbins; Hannah K Wilson; Scott G Canfield; Tongcheng Qian; Sean P Palecek; Eric V Shusta
Journal: Methods Date: 2015-10-27 Impact factor: 3.608

3. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia.

Authors: Zheng Gang Zhang; Li Zhang; Wayne Tsang; Hamid Soltanian-Zadeh; Daniel Morris; Ruilan Zhang; Anton Goussev; Cecylia Powers; Thomas Yeich; Michael Chopp
Journal: J Cereb Blood Flow Metab Date: 2002-04 Impact factor: 6.200

4. Death receptors DR6 and TROY regulate brain vascular development.

Authors: Stephen J Tam; David L Richmond; Joshua S Kaminker; Zora Modrusan; Baby Martin-McNulty; Tim C Cao; Robby M Weimer; Richard A D Carano; Nick van Bruggen; Ryan J Watts
Journal: Dev Cell Date: 2012-02-14 Impact factor: 12.270

5. Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature.

Authors: Jennifer A Macdonald; Nivetha Murugesan; Joel S Pachter
Journal: J Neurosci Res Date: 2010-05-15 Impact factor: 4.164

6. Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.

Authors: Valeria V Orlova; Francijna E van den Hil; Sandra Petrus-Reurer; Yvette Drabsch; Peter Ten Dijke; Christine L Mummery
Journal: Nat Protoc Date: 2014-05-29 Impact factor: 13.491

7. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.

Authors: Weiying Zhou; Miranda Y Fong; Yongfen Min; George Somlo; Liang Liu; Melanie R Palomares; Yang Yu; Amy Chow; Sean Timothy Francis O'Connor; Andrew R Chin; Yun Yen; Yafan Wang; Eric G Marcusson; Peiguo Chu; Jun Wu; Xiwei Wu; Arthur Xuejun Li; Zhuo Li; Hanlin Gao; Xiubao Ren; Mark P Boldin; Pengnian Charles Lin; Shizhen Emily Wang
Journal: Cancer Cell Date: 2014-04-14 Impact factor: 31.743

8. Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions.

Authors: Gopu Sriram; Jia Yong Tan; Intekhab Islam; Abdul Jalil Rufaihah; Tong Cao
Journal: Stem Cell Res Ther Date: 2015-12-30 Impact factor: 6.832

4. Transplanted hair follicle stem cells migrate to the penumbra and express neural markers in a rat model of cerebral ischaemia/reperfusion.

Authors: Xuemei Zhang; Hao Tang; Senlin Mao; Bing Li; Yinglian Zhou; Hui Yue; Duo Wang; Yifei Wang; Jin Fu
Journal: Stem Cell Res Ther Date: 2020-09-23 Impact factor: 6.832

4 in total

Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation.

1. Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema.

2. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.

3. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia.

4. Death receptors DR6 and TROY regulate brain vascular development.

5. Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature.

6. Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.

7. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.

8. Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions.

9. Effect of dexamethasone, insulin and EGF on the myogenic potential on human endometrial stem cell.

Review 10. Novel insights into the development and maintenance of the blood-brain barrier.

Review 1. Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment.

2. Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors.

Review 3. Exosomes-based therapy of stroke, an emerging approach toward recovery.

4. Transplanted hair follicle stem cells migrate to the penumbra and express neural markers in a rat model of cerebral ischaemia/reperfusion.