Yu-Jian Liu1, Jian Zhan1, Xiao-Li Liu1, Ying Wang2, Jie Ji1, Qi-Qiang He3. 1. School of Public Health, Wuhan University, Wuhan, PR China. 2. School of Public Health, Tongji Medical College, HUST, PR China. 3. School of Public Health, Wuhan University, Wuhan, PR China; Global Health Institute, Wuhan University, Wuhan, PR China. Electronic address: heqiqiang@gmail.com.
Abstract
BACKGROUND & AIMS: Flavonoids may have cardioprotective effects, but epidemiological evidence on the relationship of dietary flavonoids with diabetes has not been systematically assessed. To examine the association between dietary flavonoids and type 2 diabetes, we performed a meta-analysis on this topic. METHODS: We searched PubMed through March 2013 for relevant cohort studies that assessed total flavonoids and type 2 diabetes risks. A fixed-effect model was used to calculate the summary risk estimates. RESULTS: Four articles consisting of 6 prospective cohorts that involved 18,146 cases and 284,806 participants were identified. The summary relative risk (RR) of type 2 diabetes for the highest intake of total flavonoids compared with the lowest was 0.91 (95% confidence interval (CI): 0.87-0.96). Furthermore, an increase in the total flavonoids intake of 500mg/d was associated with a significant risk reduction of 5% (RR=0.95, 95% CI: 0.91-0.98). In subgroup analyses, the observed beneficial effects were observed in US population, in those mean age>40 years old people and in studies ≥20 years in duration. CONCLUSIONS: The present meta-analysis indicates that consumption of dietary total flavonoids is associated with a reduced risk of type 2 diabetes.
BACKGROUND & AIMS:Flavonoids may have cardioprotective effects, but epidemiological evidence on the relationship of dietary flavonoids with diabetes has not been systematically assessed. To examine the association between dietary flavonoids and type 2 diabetes, we performed a meta-analysis on this topic. METHODS: We searched PubMed through March 2013 for relevant cohort studies that assessed total flavonoids and type 2 diabetes risks. A fixed-effect model was used to calculate the summary risk estimates. RESULTS: Four articles consisting of 6 prospective cohorts that involved 18,146 cases and 284,806 participants were identified. The summary relative risk (RR) of type 2 diabetes for the highest intake of total flavonoids compared with the lowest was 0.91 (95% confidence interval (CI): 0.87-0.96). Furthermore, an increase in the total flavonoids intake of 500mg/d was associated with a significant risk reduction of 5% (RR=0.95, 95% CI: 0.91-0.98). In subgroup analyses, the observed beneficial effects were observed in US population, in those mean age>40 years old people and in studies ≥20 years in duration. CONCLUSIONS: The present meta-analysis indicates that consumption of dietary total flavonoids is associated with a reduced risk of type 2 diabetes.
Authors: Giuseppe Grosso; Agnieszka Micek; Justyna Godos; Salvatore Sciacca; Andrzej Pajak; Miguel A Martínez-González; Edward L Giovannucci; Fabio Galvano Journal: Eur J Epidemiol Date: 2016-10-03 Impact factor: 8.082
Authors: Li Zhang; Rachel N Carmody; Hetal M Kalariya; Rocio M Duran; Kristin Moskal; Alexander Poulev; Peter Kuhn; Kevin M Tveter; Peter J Turnbaugh; Ilya Raskin; Diana E Roopchand Journal: J Nutr Biochem Date: 2018-02-15 Impact factor: 6.048
Authors: Mohammad Shamsul Ola; Mohammed M Ahmed; Rehan Ahmad; Hatem M Abuohashish; Salim S Al-Rejaie; Abdullah S Alhomida Journal: J Mol Neurosci Date: 2015-05-01 Impact factor: 3.444