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Literature DB >> 23589019

YB-1 stabilizes HIV-1 genomic RNA and enhances viral production.

Xin Mu¹, Wei Li, Xinlu Wang, Guangxia Gao.

Abstract

HIV-1 utilizes cellular factors for efficient replication. The viral RNA is different from cellular mRNAs in many aspects, and is prone to attacks by cellular RNA quality control systems. To establish effective infection, the virus has evolved multiple mechanisms to protect its RNA. Here, we show that expression of the Y-box binding protein 1 (YB-1) enhanced the production of HIV-1. Downregulation of endogenous YB-1 in producer cells decreased viral production. YB-1 increased viral protein expression by stabilizing HIV-1 RNAs. The stem loop 2 in the HIV-1 RNA packaging signal was mapped to be the YB-1-responsive element. Taken together, these results indicate that YB-1 stabilizes HIV-1 genomic RNA and thereby enhances HIV-1 gene expression and viral production.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23589019 PMCID： PMC4875536 DOI： 10.1007/s13238-013-3011-3

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

24 in total

1. The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer.

Authors: V Evdokimova; P Ruzanov; H Imataka; B Raught; Y Svitkin; L P Ovchinnikov; N Sonenberg
Journal: EMBO J Date: 2001-10-01 Impact factor: 11.598

2. Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.

Authors: Jochen Deckert; Klaus Hartmuth; Daniel Boehringer; Nastaran Behzadnia; Cindy L Will; Berthold Kastner; Holger Stark; Henning Urlaub; Reinhard Lührmann
Journal: Mol Cell Biol Date: 2006-07 Impact factor: 4.272

3. A p50-like Y-box protein with a putative translational role becomes associated with pre-mRNA concomitant with transcription.

Authors: Teresa Soop; Dmitri Nashchekin; Jian Zhao; Xin Sun; Alla T Alzhanova-Ericsson; Birgitta Björkroth; Lev Ovchinnikov; Bertil Daneholt
Journal: J Cell Sci Date: 2003-04-15 Impact factor: 5.285

4. Identification of a major co-receptor for primary isolates of HIV-1.

Authors: H Deng; R Liu; W Ellmeier; S Choe; D Unutmaz; M Burkhart; P Di Marzio; S Marmon; R E Sutton; C M Hill; C B Davis; S C Peiper; T J Schall; D R Littman; N R Landau
Journal: Nature Date: 1996-06-20 Impact factor: 49.962

5. The major core protein of messenger ribonucleoprotein particles (p50) promotes initiation of protein biosynthesis in vitro.

Authors: V M Evdokimova; E A Kovrigina; D V Nashchekin; E K Davydova; J W Hershey; L P Ovchinnikov
Journal: J Biol Chem Date: 1998-02-06 Impact factor: 5.157

6. YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules.

Authors: Atsushi Kawaguchi; Ken Matsumoto; Kyosuke Nagata
Journal: J Virol Date: 2012-08-01 Impact factor: 5.103

7. Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA.

Authors: Wei Li; Xinlu Wang; Guangxia Gao
Journal: Protein Cell Date: 2012-12-08 Impact factor: 14.870

8. Y box-binding protein-1 binds to the dengue virus 3'-untranslated region and mediates antiviral effects.

Authors: Suman Marie Paranjape; Eva Harris
Journal: J Biol Chem Date: 2007-08-28 Impact factor: 5.157

9. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes.

Authors: Kosuke Miyauchi; Yuri Kim; Olga Latinovic; Vladimir Morozov; Gregory B Melikyan
Journal: Cell Date: 2009-05-01 Impact factor: 41.582

10. The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA.

Authors: Xuemin Guo; Jing Ma; Jing Sun; Guangxia Gao
Journal: Proc Natl Acad Sci U S A Date: 2006-12-21 Impact factor: 12.779

8 in total

1. A murine retrovirus co-Opts YB-1, a translational regulator and stress granule-associated protein, to facilitate virus assembly.

Authors: Darrin V Bann; Andrea R Beyer; Leslie J Parent
Journal: J Virol Date: 2014-02-05 Impact factor: 5.103

YB-1 stabilizes HIV-1 genomic RNA and enhances viral production.

1. The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer.

2. Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.

3. A p50-like Y-box protein with a putative translational role becomes associated with pre-mRNA concomitant with transcription.

4. Identification of a major co-receptor for primary isolates of HIV-1.

5. The major core protein of messenger ribonucleoprotein particles (p50) promotes initiation of protein biosynthesis in vitro.

6. YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules.

7. Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA.

8. Y box-binding protein-1 binds to the dengue virus 3'-untranslated region and mediates antiviral effects.

9. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes.

10. The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA.

1. A murine retrovirus co-Opts YB-1, a translational regulator and stress granule-associated protein, to facilitate virus assembly.

2. Identification of host proteins differentially associated with HIV-1 RNA splice variants.

3. Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.

4. Elucidating the in vivo interactome of HIV-1 RNA by hybridization capture and mass spectrometry.

5. Investigation of function and regulation of the YB-1 cellular factor in HIV replication.

6. IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells.

7. Y-Box Binding Protein 1 Interacts with Dengue Virus Nucleocapsid and Mediates Viral Assembly.

8. Y-box-binding protein 1 supports the early and late steps of HIV replication.