Literature DB >> 23225179

Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA.

Wei Li1, Xinlu Wang, Guangxia Gao.   

Abstract

Murine leukemia virus (MLV)-based retroviral vectors is widely used for gene transfer and basic research, and production of high-titer retroviral vectors is very important. Here we report that expression of the Y-box binding protein 1 (YB-1) enhanced the production of infectious MLV vectors. YB-1 specifically increased the stability of viral genomic RNA in virus-producing cells, and thus increasing viral RNA levels in both producer cells and virion particles. The viral element responsive to YB-1 was mapped to the repeat sequence (R region) in MLV genomic RNA. These results identified YB-1 as a MLV mRNA stabilizer, which can be used for improving production of MLV vectors.

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Year:  2012        PMID： 23225179      PMCID： PMC4875382          DOI： 10.1007/s13238-012-2090-x

Source DB:  PubMed          Journal:  Protein Cell        ISSN： 1674-800X            Impact factor:   14.870


  23 in total

Review 1.  Retroviral vectors.

Authors:  S H Kim; S Kim; P D Robbins
Journal:  Adv Virus Res       Date:  2000       Impact factor: 9.937

2.  The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer.

Authors:  V Evdokimova; P Ruzanov; H Imataka; B Raught; Y Svitkin; L P Ovchinnikov; N Sonenberg
Journal:  EMBO J       Date:  2001-10-01       Impact factor: 11.598

3.  The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage.

Authors:  Maxim P Nekrasov; Maria P Ivshina; Konstantin G Chernov; Elizaveta A Kovrigina; Valentina M Evdokimova; Adri A M Thomas; John W B Hershey; Lev P Ovchinnikov
Journal:  J Biol Chem       Date:  2003-02-11       Impact factor: 5.157

Review 4.  The pleiotropic functions of the Y-box-binding protein, YB-1.

Authors:  Kimitoshi Kohno; Hiroto Izumi; Takeshi Uchiumi; Megumi Ashizuka; Michihiko Kuwano
Journal:  Bioessays       Date:  2003-07       Impact factor: 4.345

5.  Kinetic analyses of stability of simple and complex retroviral vectors.

Authors:  F Higashikawa; L Chang
Journal:  Virology       Date:  2001-02-01       Impact factor: 3.616

6.  Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat.

Authors:  B E Sawaya; K Khalili; S Amini
Journal:  J Gen Virol       Date:  1998-02       Impact factor: 3.891

Review 7.  Y-box-binding protein 1 (YB-1) and its functions.

Authors:  I A Eliseeva; E R Kim; S G Guryanov; L P Ovchinnikov; D N Lyabin
Journal:  Biochemistry (Mosc)       Date:  2011-12       Impact factor: 2.487

8.  The zinc finger antiviral protein directly binds to specific viral mRNAs through the CCCH zinc finger motifs.

Authors:  Xuemin Guo; John-William N Carroll; Margaret R Macdonald; Stephen P Goff; Guangxia Gao
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

9.  The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA.

Authors:  Xuemin Guo; Jing Ma; Jing Sun; Guangxia Gao
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-21       Impact factor: 12.779

10.  Expression of IMP1 enhances production of murine leukemia virus vector by facilitating viral genomic RNA packaging.

Authors:  Yun Mai; Guangxia Gao
Journal:  PLoS One       Date:  2010-12-29       Impact factor: 3.240
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  6 in total

1.  A novel recombinant papillomavirus genome enabling in vivo RNA interference reveals that YB-1, which interacts with the viral regulatory protein E2, is required for CRPV-induced tumor formation in vivo.

Authors:  Natalie Leiprecht; Ekaterina Notz; Johanna Schuetz; Juliane Haedicke; Frank Stubenrauch; Thomas Iftner
Journal:  Am J Cancer Res       Date:  2014-05-26       Impact factor: 6.166

2.  YB-1 stabilizes HIV-1 genomic RNA and enhances viral production.

Authors:  Xin Mu; Wei Li; Xinlu Wang; Guangxia Gao
Journal:  Protein Cell       Date:  2013-04-15       Impact factor: 14.870

3.  A murine retrovirus co-Opts YB-1, a translational regulator and stress granule-associated protein, to facilitate virus assembly.

Authors:  Darrin V Bann; Andrea R Beyer; Leslie J Parent
Journal:  J Virol       Date:  2014-02-05       Impact factor: 5.103

4.  Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.

Authors:  Matthew J Shurtleff; Morayma M Temoche-Diaz; Kate V Karfilis; Sayaka Ri; Randy Schekman
Journal:  Elife       Date:  2016-08-25       Impact factor: 8.140

5.  Investigation of function and regulation of the YB-1 cellular factor in HIV replication.

Authors:  Yu-Mi Jung; Kyung-Lee Yu; Seong-Hyun Park; Seong-Deok Lee; Min-Jeong Kim; Ji-Chang You
Journal:  BMB Rep       Date:  2018-06       Impact factor: 4.778

6.  Y-box-binding protein 1 supports the early and late steps of HIV replication.

Authors:  Caroline Weydert; Bart van Heertum; Lieve Dirix; Stéphanie De Houwer; Flore De Wit; Jan Mast; Steven J Husson; Katrien Busschots; Renate König; Rik Gijsbers; Jan De Rijck; Zeger Debyser
Journal:  PLoS One       Date:  2018-07-11       Impact factor: 3.240
  6 in total

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