Literature DB >> 23587961

Efficacy of tigecycline alone and in combination with gentamicin in the treatment of experimental endocarditis due to linezolid-resistant Enterococcus faecium.

Konstantinos Pontikis1, Angelos Pefanis, Thomas Tsaganos, Ira-Maria Tzepi, Dionyssia-Pinelopi Carrer, Helen Giamarellou.   

Abstract

We evaluated the efficacy of tigecycline in a rabbit model of experimental endocarditis caused by a linezolid-resistant clinical strain of Enterococcus faecium. Tigecycline-treated animals had a 2.8-log10-CFU/g reduction in microbial counts in excised vegetations compared with controls. Addition of gentamicin caused a further arithmetical reduction in colony counts. The therapeutic effect was sustained 5 days after completion of treatment, as shown by relapse studies performed in treatment groups.

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Year:  2013        PMID： 23587961      PMCID： PMC3697324          DOI： 10.1128/AAC.00646-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Enterococcal endocarditis: can we win the war?

Authors:  Jose M Munita; Cesar A Arias; Barbara E Murray
Journal:  Curr Infect Dis Rep       Date:  2012-08       Impact factor: 3.725

Review 2.  Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.

Authors:  Kenneth N Agwuh; Alasdair MacGowan
Journal:  J Antimicrob Chemother       Date:  2006-07-01       Impact factor: 5.790

3.  Importance of using relapse studies or tests for detection of antibiotic resistance before considering that a treatment for multidrug-resistant enterococcal experimental endocarditis is effective.

Authors:  F Caron
Journal:  J Infect Dis       Date:  1997-01       Impact factor: 5.226

4.  Pharmacokinetics-pharmacodynamics of tigecycline in patients with community-acquired pneumonia.

Authors:  Christopher M Rubino; Sujata M Bhavnani; Alan Forrest; Gary Dukart; Nathalie Dartois; Angel Cooper; Joan Korth-Bradley; Paul G Ambrose
Journal:  Antimicrob Agents Chemother       Date:  2011-10-03       Impact factor: 5.191

5.  Multidrug-resistant Enterococcus faecium endocarditis treated with combination tigecycline and high-dose daptomycin.

Authors:  Amanda C Schutt; Nicole M Bohm
Journal:  Ann Pharmacother       Date:  2009-11-03       Impact factor: 3.154

6.  An international activity and spectrum analysis of linezolid: ZAAPS Program results for 2011.

Authors:  Robert K Flamm; Rodrigo E Mendes; James E Ross; Helio S Sader; Ronald N Jones
Journal:  Diagn Microbiol Infect Dis       Date:  2013-03-09       Impact factor: 2.803

7.  Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineage.

Authors:  Maria Grazia Bonora; Maurizio Solbiati; Erminia Stepan; Antonella Zorzi; Aldo Luzzani; Maria Rosaria Catania; Roberta Fontana
Journal:  J Clin Microbiol       Date:  2006-03       Impact factor: 5.948

8.  Colonisation with vancomycin- and linezolid-resistant Enterococcus faecium in a university hospital: molecular epidemiology and risk factor analysis.

Authors:  Maria Souli; Vissaria Sakka; Irene Galani; Anastasia Antoniadou; Lambrini Galani; Nikolaos Siafakas; Loukia Zerva; Helen Fytrou; Sotirios Tsiodras; Helen Giamarellou
Journal:  Int J Antimicrob Agents       Date:  2008-11-13       Impact factor: 5.283

Review 9.  Tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies.

Authors:  J M Entenza; P Moreillon
Journal:  Int J Antimicrob Agents       Date:  2009-01-21       Impact factor: 5.283

10.  Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart.

Authors:  B B Perlman; L R Freedman
Journal:  Yale J Biol Med       Date:  1971-10
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  2 in total

Review 1.  Combination antibiotic therapy for the treatment of infective endocarditis due to enterococci.

Authors:  Sebastiano Leone; Silvana Noviello; Silvano Esposito
Journal:  Infection       Date:  2015-09-01       Impact factor: 3.553

2.  Tigecycline and Gentamicin-Combined Treatment Enhances Renal Damage: Oxidative Stress, Inflammatory Reaction, and Apoptosis Interplay.

Authors:  Dina Elgazzar; Mohamed Aboubakr; Heba Bayoumi; Amany N Ibrahim; Safwa M Sorour; Mohamed El-Hewaity; Abulmaaty M Elsayed; Shaimaa A Shehata; Khaled A Bayoumi; Mohammed Alsieni; Maged Behery; Doaa Abdelrahaman; Samah F Ibrahim; Ahmed Abdeen
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-10
  2 in total

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