Sebastiano Leone1, Silvana Noviello2, Silvano Esposito3. 1. Department of Infectious Diseases, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona, Università di Salerno, Largo Città di Ippocrate, 84131, Salerno, Italy. sebastianoleone@yahoo.it. 2. Department of Infectious Diseases, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona, Università di Salerno, Largo Città di Ippocrate, 84131, Salerno, Italy. 3. Department of Infectious Diseases, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona, Università di Salerno, Largo Città di Ippocrate, 84131, Salerno, Italy. siesposito@unisa.it.
Abstract
INTRODUCTION: Enterococci are common causes of infective endocarditis (IE) in both health care and community-based setting. Enterococcal IE requires bactericidal therapy for an optimal outcome. For decades, cell-wall-active antimicrobial agents (penicillins or vancomycin) in combination with aminoglycosides were the cornerstone of the treatment; however, the emergence of antibiotic resistance has significantly reduced the efficacy of these regimens. MATERIALS AND METHODS: Data for this review were identified by searches of MEDLINE and references from relevant articles on antibiotic combination regimens for the treatment of enterococcal IE. Abstracts presented in scientific conferences were not searched for. CONCLUSION: New effective and safe combination treatments, including double-β-lactam and daptomycin/β-lactam combination, are proving useful for the management of IE due to enterococci.
INTRODUCTION: Enterococci are common causes of infective endocarditis (IE) in both health care and community-based setting. Enterococcal IE requires bactericidal therapy for an optimal outcome. For decades, cell-wall-active antimicrobial agents (penicillins or vancomycin) in combination with aminoglycosides were the cornerstone of the treatment; however, the emergence of antibiotic resistance has significantly reduced the efficacy of these regimens. MATERIALS AND METHODS: Data for this review were identified by searches of MEDLINE and references from relevant articles on antibiotic combination regimens for the treatment of enterococcal IE. Abstracts presented in scientific conferences were not searched for. CONCLUSION: New effective and safe combination treatments, including double-β-lactam and daptomycin/β-lactam combination, are proving useful for the management of IE due to enterococci.
Authors: S Leone; V Ravasio; E Durante-Mangoni; M Crapis; G Carosi; P G Scotton; N Barzaghi; M Falcone; P Chinello; M B Pasticci; P Grossi; R Utili; P Viale; M Rizzi; F Suter Journal: Infection Date: 2012-06-19 Impact factor: 3.553
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Authors: Manuela Carugati; Arnold S Bayer; Josè M Miró; Lawrence P Park; Armenio C Guimarães; Athanasios Skoutelis; Claudio Q Fortes; Emanuele Durante-Mangoni; Margaret M Hannan; Francisco Nacinovich; Nuria Fernández-Hidalgo; Paolo Grossi; Ru-San Tan; Thomas Holland; Vance G Fowler; Ralph G Corey; Vivian H Chu Journal: Antimicrob Agents Chemother Date: 2013-09-30 Impact factor: 5.191
Authors: Ivone Jimenez-Toro; Carlos A Rodriguez; Andres F Zuluaga; Julian D Otalvaro; Omar Vesga Journal: PLoS One Date: 2020-12-08 Impact factor: 3.240
Authors: Marco Fiore; Alberto Enrico Maraolo; Ivan Gentile; Guglielmo Borgia; Sebastiano Leone; Pasquale Sansone; Maria Beatrice Passavanti; Caterina Aurilio; Maria Caterina Pace Journal: World J Hepatol Date: 2017-10-28