Rhea Powell1, Duncan Davidson1, Jasmin Divers2, Ani Manichaikul3, J Jeffrey Carr4, Robert Detrano5, Eric A Hoffman6, Rui Jiang1, Richard A Kronmal7, Kiang Liu8, Naresh M Punjabi9, Eyal Shahar10, Karol E Watson11, Jerome I Rotter12, Kent D Taylor12, Stephen S Rich3, R Graham Barr1,13. 1. Department of Medicine, Columbia University Medical Center, New York, NY. 2. Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC. 3. Center for Public Health Genomics, University of Virginia, Charlottesville, VA. 4. Department of Radiology, Division of Radiological Sciences, Wake-Forest University, Winston-Salem, NC. 5. Department of Radiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA. 6. Department of Radiology, University of Iowa, Iowa City, IA. 7. Department of Biostatistics, University of Washington, Seattle, WA. 8. Department of Preventative Medicine, Northwestern University Medical School, Chicago, IL. 9. Department of Medicine, Johns Hopkins University, Baltimore, MD. 10. Division of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ. 11. Department of Medicine, University of California at Los Angeles, Los Angeles, CA. 12. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA. 13. Department of Epidemiology, Columbia University Medical Center, New York, NY.
Abstract
BACKGROUND: Cigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity. OBJECTIVE: To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans. DESIGN: Cross-sectional population-based study of adults age 45-84 years in the USA. MEASUREMENTS: Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirometry measured for 3344 participants; and per cent emphysema on computed tomography for 8224 participants. RESULTS: The prevalence of ever-smoking was: Caucasians, 57.6%; African-Americans, 56.4%; Hispanics, 46.7%; and Chinese-Americans, 26.8%. Every 10 pack-years was associated with -0.73% (95% CI -0.90% to -0.56%) decrement in the forced expiratory volume in 1 s to forced vital capacity (FEV1 to FVC) and a 0.23% (95% CI 0.08% to 0.38%) increase in per cent emphysema. There was no evidence that relationships of pack-years to the FEV1 to FVC, airflow obstruction and per cent emphysema varied by genetic ancestry (all p>0.10), self-reported race/ethnicity (all p>0.10) or, among African-Americans, African ancestry. There were small differences in relationships of pack-years to the FEV1 among male Chinese-Americans and to the FEV1 to FVC ratio with African and Native American ancestry among male Hispanics only. CONCLUSIONS: In this large cohort, there was little to no evidence that the associations of smoking to lung function and per cent emphysema differed by genetic ancestry or self-reported race/ethnicity.
BACKGROUND: Cigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity. OBJECTIVE: To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans. DESIGN: Cross-sectional population-based study of adults age 45-84 years in the USA. MEASUREMENTS: Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirometry measured for 3344 participants; and per cent emphysema on computed tomography for 8224 participants. RESULTS: The prevalence of ever-smoking was: Caucasians, 57.6%; African-Americans, 56.4%; Hispanics, 46.7%; and Chinese-Americans, 26.8%. Every 10 pack-years was associated with -0.73% (95% CI -0.90% to -0.56%) decrement in the forced expiratory volume in 1 s to forced vital capacity (FEV1 to FVC) and a 0.23% (95% CI 0.08% to 0.38%) increase in per cent emphysema. There was no evidence that relationships of pack-years to the FEV1 to FVC, airflow obstruction and per cent emphysema varied by genetic ancestry (all p>0.10), self-reported race/ethnicity (all p>0.10) or, among African-Americans, African ancestry. There were small differences in relationships of pack-years to the FEV1 among male Chinese-Americans and to the FEV1 to FVC ratio with African and Native American ancestry among male Hispanics only. CONCLUSIONS: In this large cohort, there was little to no evidence that the associations of smoking to lung function and per cent emphysema differed by genetic ancestry or self-reported race/ethnicity.
Entities:
Keywords:
COPD epidemiology; Emphysema; Tobacco and the lung
Authors: Rajesh Kumar; Max A Seibold; Melinda C Aldrich; L Keoki Williams; Alex P Reiner; Laura Colangelo; Joshua Galanter; Christopher Gignoux; Donglei Hu; Saunak Sen; Shweta Choudhry; Edward L Peterson; Jose Rodriguez-Santana; William Rodriguez-Cintron; Michael A Nalls; Tennille S Leak; Ellen O'Meara; Bernd Meibohm; Stephen B Kritchevsky; Rongling Li; Tamara B Harris; Deborah A Nickerson; Myriam Fornage; Paul Enright; Elad Ziv; Lewis J Smith; Kiang Liu; Esteban González Burchard Journal: N Engl J Med Date: 2010-07-07 Impact factor: 91.245
Authors: Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich Journal: Nat Genet Date: 2006-07-23 Impact factor: 38.330
Authors: Shannon Bruse; Akshay Sood; Hans Petersen; Yushi Liu; Shuguang Leng; Juan C Celedón; Frank Gilliland; Bartolomé Celli; Steven A Belinsky; Yohannes Tesfaigzi Journal: Am J Respir Crit Care Med Date: 2011-09-08 Impact factor: 21.405
Authors: W M Vollmer; Thorn Gíslason; P Burney; P L Enright; A Gulsvik; A Kocabas; A S Buist Journal: Eur Respir J Date: 2009-05-21 Impact factor: 16.671
Authors: Alejandro A Diaz; Carolyn E Come; David M Mannino; Victor Pinto-Plata; Miguel J Divo; Carol Bigelow; Bartolome Celli; George R Washko Journal: Chest Date: 2014-02 Impact factor: 9.410
Authors: Elizabeth C Oelsner; Victor E Ortega; Benjamin M Smith; Jennifer N Nguyen; Ani W Manichaikul; Eric A Hoffman; Xiuqing Guo; Kent D Taylor; Prescott G Woodruff; David J Couper; Nadia N Hansel; Fernando J Martinez; Robert Paine; Meilan K Han; Christopher Cooper; Mark T Dransfield; Gerard Criner; Jerry A Krishnan; Russell Bowler; Eugene R Bleecker; Stephen Peters; Stephen S Rich; Deborah A Meyers; Jerome I Rotter; R Graham Barr Journal: Am J Respir Crit Care Med Date: 2019-09-15 Impact factor: 21.405
Authors: Alejandro A Diaz; Farbod N Rahaghi; Tracy J Doyle; Thomas P Young; Erick S Maclean; Carlos H Martinez; Raul San José Estépar; Stefano Guerra; Yohannes Tesfaigzi; Ivan O Rosas; George R Washko; David O Wilson Journal: Chronic Obstr Pulm Dis Date: 2017-09-05
Authors: Elizabeth C Oelsner; Eric A Hoffman; Aaron R Folsom; J Jeffrey Carr; Paul L Enright; Steven M Kawut; Richard Kronmal; David Lederer; Joao A C Lima; Gina S Lovasi; Steven Shea; R Graham Barr Journal: Ann Intern Med Date: 2014-12-16 Impact factor: 25.391
Authors: Benjamin M Smith; Hussein Traboulsi; John H M Austin; Ani Manichaikul; Eric A Hoffman; Eugene R Bleecker; Wellington V Cardoso; Christopher Cooper; David J Couper; Stephen M Dashnaw; Jia Guo; MeiLan K Han; Nadia N Hansel; Emlyn W Hughes; David R Jacobs; Richard E Kanner; Joel D Kaufman; Eric Kleerup; Ching-Long Lin; Kiang Liu; Christian M Lo Cascio; Fernando J Martinez; Jennifer N Nguyen; Martin R Prince; Stephen Rennard; Stephen S Rich; Leora Simon; Yanping Sun; Karol E Watson; Prescott G Woodruff; Carolyn J Baglole; R Graham Barr Journal: Proc Natl Acad Sci U S A Date: 2018-01-16 Impact factor: 11.205
Authors: R Graham Barr; Larissa Avilés-Santa; Sonia M Davis; Tom K Aldrich; Franklyn Gonzalez; Ashley G Henderson; Robert C Kaplan; Lisa LaVange; Kiang Liu; Jose S Loredo; Eliana S Mendes; Ai Ni; Andrew Ries; Matthias Salathe; Lewis J Smith Journal: Am J Respir Crit Care Med Date: 2016-02-15 Impact factor: 21.405
Authors: Michael H Cho; Merry-Lynn N McDonald; Xiaobo Zhou; Manuel Mattheisen; Peter J Castaldi; Craig P Hersh; Dawn L Demeo; Jody S Sylvia; John Ziniti; Nan M Laird; Christoph Lange; Augusto A Litonjua; David Sparrow; Richard Casaburi; R Graham Barr; Elizabeth A Regan; Barry J Make; John E Hokanson; Sharon Lutz; Tanda Murray Dudenkov; Homayoon Farzadegan; Jacqueline B Hetmanski; Ruth Tal-Singer; David A Lomas; Per Bakke; Amund Gulsvik; James D Crapo; Edwin K Silverman; Terri H Beaty Journal: Lancet Respir Med Date: 2014-02-07 Impact factor: 30.700