Literature DB >> 2358373

The effects of acetylsalicylic acid on phosphoenolpyruvate carboxykinase activity and acinar heterotopy in livers from juvenile and adult rats.

M Wimmer1, C Luttringer, M Colombi.   

Abstract

Male and female juvenile as well as adult rats were treated with acetylsalicylic acid in order to examine the effect of the drug on over-all activity and activity distribution of phosphoenolpyruvate carboxykinase (PEPCK) in the liver acinus. Upon administration of acetylsalicylic acid PEPCK activity increased in juvenile males and adult females, but was reduced in juvenile females and adult males. The periportal-perivenous activity gradient along the sinusoidal length, which is flatter in untreated juvenile rats compared to the livers of adult rats, was distinctly steepened by acetylsalicylic acid treatment. Acetylsalicylic acid did not affect the gradient in adult rats.

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Year:  1990        PMID： 2358373     DOI： 10.1007/bf02440181

Source DB:  PubMed          Journal:  Histochemistry        ISSN： 0301-5564


  20 in total

1.  Changes with age in levels of serum gonadotropins, prolactin and gonadal steroids in prepubertal male and female rats.

Authors:  K D Döhler; W Wuttke
Journal:  Endocrinology       Date:  1975-10       Impact factor: 4.736

2.  Heterogeneous reciprocal localization of fructose-1,6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue.

Authors:  N Katz; H F Teutsch; K Jungermann; D Sasse
Journal:  FEBS Lett       Date:  1977-11-15       Impact factor: 4.124

3.  Metabolic zonation in liver of diabetic rats. Zonal distribution of phosphoenolpyruvate carboxykinase, pyruvate kinase, glucose-6-phosphatase and succinate dehydrogenase.

Authors:  H Miethke; B Wittig; A Nath; S Zierz; K Jungermann
Journal:  Biol Chem Hoppe Seyler       Date:  1985-05

4.  Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule.

Authors:  J G Conway; F C Kauffman; T Tsukada; R G Thurman
Journal:  Mol Pharmacol       Date:  1984-05       Impact factor: 4.436

5.  Changes in the acinar activity patterns of phosphoenolpyruvate carboxykinase in livers of male and female rats upon feeding a high protein and a high fat diet.

Authors:  M Wimmer; C Luttringer; M Colombi
Journal:  Histochemistry       Date:  1990

6.  Drug metabolism by periportal and perivenous rat hepatocytes. Comparison of phase I and phase II reactions and their inducibility during culture.

Authors:  E M Suolinna; K E Penttilä; B M Winell; A C Sjöholm; K O Lindros
Journal:  Biochem Pharmacol       Date:  1989-04-15       Impact factor: 5.858

7.  The development of the acinar heterotopic pattern of phosphoenolpyruvate carboxykinase activity in the newborn rat.

Authors:  M Wimmer; C Luttringer; M Colombi
Journal:  Histochemistry       Date:  1990

8.  The effect of sex hormones on the acinar distribution pattern of phosphoenolpyruvate carboxykinase activity in rat liver.

Authors:  M Wimmer
Journal:  Biol Chem Hoppe Seyler       Date:  1989-07

9.  Sex differences of the influence of T3 on the topical distribution of phosphoenolpyruvate carboxykinase activity in the liver acinus.

Authors:  M Wimmer
Journal:  Histochemistry       Date:  1989

10.  A bioluminescent assay for the determination of phosphoenolpyruvate carboxykinase activity in nanogram-sized tissue samples.

Authors:  M Wimmer
Journal:  Anal Biochem       Date:  1988-05-01       Impact factor: 3.365
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  1 in total

1.  Liver lipid profiles of adults taking therapeutic doses of aspirin.

Authors:  J L Rabinowitz; D G Baker; T G Villanueva; A P Asanza; D M Capuzzi
Journal:  Lipids       Date:  1992-04       Impact factor: 1.880
  1 in total

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