Literature DB >> 23571848

The Regional Healthcare Ecosystem Analyst (RHEA): a simulation modeling tool to assist infectious disease control in a health system.

Bruce Y Lee1, Kim F Wong, Sarah M Bartsch, S Levent Yilmaz, Taliser R Avery, Shawn T Brown, Yeohan Song, Ashima Singh, Diane S Kim, Susan S Huang.   

Abstract

OBJECTIVE: As healthcare systems continue to expand and interconnect with each other through patient sharing, administrators, policy makers, infection control specialists, and other decision makers may have to take account of the entire healthcare 'ecosystem' in infection control.
MATERIALS AND METHODS: We developed a software tool, the Regional Healthcare Ecosystem Analyst (RHEA), that can accept user-inputted data to rapidly create a detailed agent-based simulation model (ABM) of the healthcare ecosystem (ie, all healthcare facilities, their adjoining community, and patient flow among the facilities) of any region to better understand the spread and control of infectious diseases.
RESULTS: To demonstrate RHEA's capabilities, we fed extensive data from Orange County, California, USA, into RHEA to create an ABM of a healthcare ecosystem and simulate the spread and control of methicillin-resistant Staphylococcus aureus. Various experiments explored the effects of changing different parameters (eg, degree of transmission, length of stay, and bed capacity). DISCUSSION: Our model emphasizes how individual healthcare facilities are components of integrated and dynamic networks connected via patient movement and how occurrences in one healthcare facility may affect many other healthcare facilities.
CONCLUSIONS: A decision maker can utilize RHEA to generate a detailed ABM of any healthcare system of interest, which in turn can serve as a virtual laboratory to test different policies and interventions.

Entities:  

Keywords:  Healthcare System; Hospital Acquired Infections; Hospitals; Infectious Diseases; Patient Sharing

Mesh:

Year:  2013        PMID: 23571848      PMCID: PMC3715346          DOI: 10.1136/amiajnl-2012-001107

Source DB:  PubMed          Journal:  J Am Med Inform Assoc        ISSN: 1067-5027            Impact factor:   4.497


  26 in total

1.  Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: resistance is a regional problem.

Authors:  David L Smith; Jonathan Dushoff; Eli N Perencevich; Anthony D Harris; Simon A Levin
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-25       Impact factor: 11.205

2.  Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units.

Authors:  Susan S Huang; Sheryl L Rifas-Shiman; David K Warren; Victoria J Fraser; Michael W Climo; Edward S Wong; Sara E Cosgrove; Trish M Perl; Jean M Pottinger; Loreen A Herwaldt; John A Jernigan; Jerome L Tokars; Daniel J Diekema; Virginia L Hinrichsen; Deborah S Yokoe; Richard Platt
Journal:  J Infect Dis       Date:  2006-12-27       Impact factor: 5.226

3.  Digital decision making: computer models and antibiotic prescribing in the twenty-first century.

Authors:  Bruce Y Lee
Journal:  Clin Infect Dis       Date:  2008-04-15       Impact factor: 9.079

4.  The potential regional impact of contact precaution use in nursing homes to control methicillin-resistant Staphylococcus aureus.

Authors:  Bruce Y Lee; Ashima Singh; Sarah M Bartsch; Kim F Wong; Diane S Kim; Taliser R Avery; Shawn T Brown; Courtney R Murphy; S Levent Yilmaz; Susan S Huang
Journal:  Infect Control Hosp Epidemiol       Date:  2012-12-18       Impact factor: 3.254

5.  A stochastic mathematical model of methicillin resistant Staphylococcus aureus transmission in an intensive care unit: predicting the impact of interventions.

Authors:  E S McBryde; A N Pettitt; D L S McElwain
Journal:  J Theor Biol       Date:  2006-11-17       Impact factor: 2.691

6.  Strategic interactions in multi-institutional epidemics of antibiotic resistance.

Authors:  David L Smith; Simon A Levin; Ramanan Laxminarayan
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-26       Impact factor: 11.205

7.  Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients.

Authors:  Stephan Harbarth; Carolina Fankhauser; Jacques Schrenzel; Jan Christenson; Pascal Gervaz; Catherine Bandiera-Clerc; Gesuele Renzi; Nathalie Vernaz; Hugo Sax; Didier Pittet
Journal:  JAMA       Date:  2008-03-12       Impact factor: 56.272

8.  Meticillin-resistant Staphylococcus aureus (MRSA) in hospitals and the community: model predictions based on the UK situation.

Authors:  J V Robotham; C A Scarff; D R Jenkins; G F Medley
Journal:  J Hosp Infect       Date:  2007-06       Impact factor: 3.926

9.  Methicillin-resistant-Staphylococcus aureus hospitalizations, United States.

Authors:  Matthew J Kuehnert; Holly A Hill; Benjamin A Kupronis; Jerome I Tokars; Steven L Solomon; Daniel B Jernigan
Journal:  Emerg Infect Dis       Date:  2005-06       Impact factor: 6.883

10.  Staphylococcus aureus-associated skin and soft tissue infections in ambulatory care.

Authors:  Linda F McCaig; L Clifford McDonald; Sanjay Mandal; Daniel B Jernigan
Journal:  Emerg Infect Dis       Date:  2006-11       Impact factor: 6.883

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  19 in total

1.  iMAGE cloud: medical image processing as a service for regional healthcare in a hybrid cloud environment.

Authors:  Li Liu; Weiping Chen; Min Nie; Fengjuan Zhang; Yu Wang; Ailing He; Xiaonan Wang; Gen Yan
Journal:  Environ Health Prev Med       Date:  2016-10-25       Impact factor: 3.674

2.  Designing a Model of a Digital Ecosystem for Healthcare and Wellness Using the Business Model Canvas.

Authors:  María Cosio León; Juan Ivan Nieto-Hipólito; Julián Garibaldi-Beltrán; Guillermo Amaya-Parra; Priscy Luque-Morales; Pedro Magaña-Espinoza; José Aguilar-Velazco
Journal:  J Med Syst       Date:  2016-04-27       Impact factor: 4.460

3.  Impact of Delays between Clinical and Laboratory Standards Institute and Food and Drug Administration Revisions of Interpretive Criteria for Carbapenem-Resistant Enterobacteriaceae.

Authors:  Sarah M Bartsch; Susan S Huang; Kim F Wong; Rachel B Slayton; James A McKinnell; Daniel F Sahm; Krystyna Kazmierczak; Leslie E Mueller; John A Jernigan; Bruce Y Lee
Journal:  J Clin Microbiol       Date:  2016-08-31       Impact factor: 5.948

4.  Cost-effectiveness of strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in an intensive care unit.

Authors:  Courtney A Gidengil; Charlene Gay; Susan S Huang; Richard Platt; Deborah Yokoe; Grace M Lee
Journal:  Infect Control Hosp Epidemiol       Date:  2015-01       Impact factor: 3.254

5.  Whole-Genome Sequencing To Identify Drivers of Carbapenem-Resistant Klebsiella pneumoniae Transmission within and between Regional Long-Term Acute-Care Hospitals.

Authors:  Jennifer H Han; Zena Lapp; Frederic Bushman; Ebbing Lautenbach; Ellie J C Goldstein; Lisa Mattei; Casey E Hofstaedter; Dorothy Kim; Irving Nachamkin; Charles Garrigan; Tanya Jain; Warren Bilker; Hannah M Wolford; Rachel B Slayton; Jacqueleen Wise; Pam Tolomeo; Evan S Snitkin
Journal:  Antimicrob Agents Chemother       Date:  2019-10-22       Impact factor: 5.191

6.  Tracking the spread of carbapenem-resistant Enterobacteriaceae (CRE) through clinical cultures alone underestimates the spread of CRE even more than anticipated.

Authors:  Bruce Y Lee; Sarah M Bartsch; Kim F Wong; Diane S Kim; Chenghua Cao; Leslie E Mueller; Gabrielle M Gussin; James A McKinnell; Loren G Miller; Susan S Huang
Journal:  Infect Control Hosp Epidemiol       Date:  2019-03-28       Impact factor: 3.254

7.  The Economic Value of the Centers for Disease Control and Prevention Carbapenem-Resistant Enterobacteriaceae Toolkit.

Authors:  Sarah M Bartsch; Susan S Huang; James A McKinnell; Kim F Wong; Leslie E Mueller; Loren G Miller; Bruce Y Lee
Journal:  Infect Control Hosp Epidemiol       Date:  2018-03-19       Impact factor: 3.254

8.  Synthesizing Marketing, Community Engagement, and Systems Science Approaches for Advancing Translational Research.

Authors:  Shawn M Kneipp; Jennifer Leeman; Pamela McCall; Kristen Hassmiller-Lich; Georgiy Bobashev; Todd A Schwartz; Robert Gilmore; Scott Riggan; Benjamin Gil
Journal:  ANS Adv Nurs Sci       Date:  2015 Jul-Sep       Impact factor: 1.824

9.  Knowing More of the Iceberg: How Detecting a Greater Proportion of Carbapenem-Resistant Enterobacteriaceae Carriers Influences Transmission.

Authors:  Sarah M Bartsch; Kim F Wong; Owen J Stokes-Cawley; James A McKinnell; Chenghua Cao; Gabrielle M Gussin; Leslie E Mueller; Diane S Kim; Loren G Miller; Susan S Huang; Bruce Y Lee
Journal:  J Infect Dis       Date:  2020-05-11       Impact factor: 7.759

10.  How Long-Term Acute Care Hospitals Can Play an Important Role in Controlling Carbapenem-Resistant Enterobacteriaceae in a Region: A Simulation Modeling Study.

Authors:  Bruce Y Lee; Sarah M Bartsch; Michael Y Lin; Lindsey Asti; Joel Welling; Leslie E Mueller; Jim Leonard; Shawn T Brown; Kruti Doshi; Sarah K Kemble; Elizabeth A Mitgang; Robert A Weinstein; William E Trick; Mary K Hayden
Journal:  Am J Epidemiol       Date:  2021-02-01       Impact factor: 4.897

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