Khadem Ali1, Ayesha Ashraf, Nripendra Nath Biswas. 1. Biotechnology Department, Biological Science School, Chung Ang University, Ansung Kyunggido 456-756, Republic of South Korea ; Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh.
Abstract
OBJECTIVE: To explore the efficacy of ethanolic leaf extract of Typhonium trilobatum L. Schott in treating diarrhea, pain and inflammation using experimental models. METHODS: In the present study, acetic acid-induced writhing, xylene-induced ear edema and castor oil-induced diarrheal model were used to evaluate the analgesic, anti-inflammatory and anti-diarrheal activities, respectively. Acute toxicity test was carried out to fix the safe doses of the plant extract. RESULTS: The plant extract demonstrated a significant inhibition of writhing (P<0.01) compared with the control group in acetic acid-induced writhing test in mice. The extract also significantly inhibited the xylene induced ear edema formation (P<0.05). In anti-diarrheal test, the extract significantly decreased the frequency of defecation and increased the mean latent period (P<0.01) in castor oil-induced diarrheal model mice at the doses of 250 and 500 mg/kg body weight. CONCLUSIONS: These results suggest that the extract possesses significant analgesic, anti-inflammatory and anti-diarrheal activities that support to the ethnopharmacological uses of this plant.
OBJECTIVE: To explore the efficacy of ethanolic leaf extract of Typhonium trilobatum L. Schott in treating diarrhea, pain and inflammation using experimental models. METHODS: In the present study, acetic acid-induced writhing, xylene-induced ear edema and castor oil-induced diarrheal model were used to evaluate the analgesic, anti-inflammatory and anti-diarrheal activities, respectively. Acute toxicity test was carried out to fix the safe doses of the plant extract. RESULTS: The plant extract demonstrated a significant inhibition of writhing (P<0.01) compared with the control group in acetic acid-induced writhing test in mice. The extract also significantly inhibited the xylene induced ear edema formation (P<0.05). In anti-diarrheal test, the extract significantly decreased the frequency of defecation and increased the mean latent period (P<0.01) in castor oil-induced diarrheal model mice at the doses of 250 and 500 mg/kg body weight. CONCLUSIONS: These results suggest that the extract possesses significant analgesic, anti-inflammatory and anti-diarrheal activities that support to the ethnopharmacological uses of this plant.
Authors: Bamidele V Owoyele; Abdulrazaq B Nafiu; Idris A Oyewole; Lukuman A Oyewole; Ayodele O Soladoye Journal: J Ethnopharmacol Date: 2008-12-07 Impact factor: 4.360
Authors: Arpona Hira; Shubhra Kanti Dey; Md Sariful Islam Howlader; Arif Ahmed; Hemayet Hossain; Ismet Ara Jahan Journal: Asian Pac J Trop Biomed Date: 2013-09-04