OBJECTIVE: To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell. METHODS: In vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope. RESULTS: The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner. CONCLUSIONS: The results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.
OBJECTIVE: To investigate the cytotoxic effect of Elaeis guineensismethanol extract on MCF-7 and Vero cell. METHODS: In vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope. RESULTS: The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner. CONCLUSIONS: The results suggest the probable use of the Elaeis guineensismethanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.
Authors: Mai M Al-Oqail; Ebtesam S Al-Sheddi; Maqsood A Siddiqui; Javed Musarrat; Abdulaziz A Al-Khedhairy; Nida N Farshori Journal: Pharmacogn Mag Date: 2015-10 Impact factor: 1.085
Authors: Muhammad Luqman Nordin; Arifah Abdul Kadir; Zainul Amiruddin Zakaria; Fauziah Othman; Rasedee Abdullah; Muhammad Nazrul Hakim Abdullah Journal: Evid Based Complement Alternat Med Date: 2017-03-16 Impact factor: 2.629
Authors: Soek Sin Teh; Gwendoline Cheng Lian Ee; Siau Hui Mah; Yoke Keong Yong; Yang Mooi Lim; Mawardi Rahmani; Zuraini Ahmad Journal: Biomed Res Int Date: 2013-09-08 Impact factor: 3.411