| Literature DB >> 23567953 |
Fatma A Ragab1, Nagwa M Abdel Gawad, Hanan H Georgey, Mona F Said.
Abstract
Some novel 1,3,4-trisubstituted pyrazoles were synthesized and screened for their anti-inflammatory and analgesic activities as well as their ulcerogenic liability. They showed anti-inflammatory and analgesic activities with better GIT tolerance than the standard drug phenylbutazone. In addition, IC50 values for 5e and 8e were recorded. Compound 5e was found to be the most active one as anti-inflammatory and analgesic agent. On the other hand, COX-1/COX-2 isozyme selectivity was also done which showed equal inhibition to both isoforms.Entities:
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Year: 2013 PMID： 23567953 DOI： 10.1016/j.ejmech.2013.03.005
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514