Literature DB >> 23567381

Going beyond antidepressant monotherapy for incomplete response in nonpsychotic late-life depression: a critical review.

Donovan T Maust1, David W Oslin, Michael E Thase.   

Abstract

Many older adults with major depressive disorder (MDD) do not respond to antidepressant monotherapy. Although there are evidence-based treatment options to support treatment beyond monotherapy for adults, the evidence for such strategies, specifically in late-life MDD, is relatively scarce. This review examines the published data describing strategies for antidepressant augmentation or acceleration studied specifically in older adults, including lithium, stimulants, and second-generation antipsychotics. In addition, the authors suggest strategies for future research, such as study of specific agents, refining understanding of the impact of medical or cognitive comorbidity in late-life depression, and comparative effectiveness to examine methods already used in clinical practice.
Copyright © 2013 American Association for Geriatric Psychiatry. All rights reserved.

Entities:  

Keywords:  Antidepressant; augmentation; depression; pharmacotherapy

Mesh：

Substances：

Year:  2013        PMID： 23567381      PMCID： PMC3543487          DOI： 10.1097/JGP.0b013e31826576cf

Source DB:  PubMed          Journal:  Am J Geriatr Psychiatry        ISSN： 1064-7481            Impact factor:   4.105


  55 in total

1.  Discontinuation of lithium augmentation in an elderly cohort.

Authors:  S Fahy; B A Lawlor
Journal:  Int J Geriatr Psychiatry       Date:  2001-10       Impact factor: 3.485

2.  Maximizing efficiency and impact in effectiveness and services research.

Authors:  David A Chambers; Philip S Wang; Thomas R Insel
Journal:  Gen Hosp Psychiatry       Date:  2010-08-24       Impact factor: 3.238

3.  Rates and predictors of mortality in an aging, rural, community-based cohort: the role of depression.

Authors:  Mary Ganguli; Hiroko H Dodge; Benoit H Mulsant
Journal:  Arch Gen Psychiatry       Date:  2002-11

4.  Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial.

Authors:  Jürgen Unützer; Wayne Katon; Christopher M Callahan; John W Williams; Enid Hunkeler; Linda Harpole; Marc Hoffing; Richard D Della Penna; Polly Hitchcock Noël; Elizabeth H B Lin; Patricia A Areán; Mark T Hegel; Lingqi Tang; Thomas R Belin; Sabine Oishi; Christopher Langston
Journal:  JAMA       Date:  2002-12-11       Impact factor: 56.272

Review 5.  Antidepressant versus placebo for depressed elderly.

Authors:  K Wilson; P Mottram; A Sivanranthan; A Nightingale
Journal:  Cochrane Database Syst Rev       Date:  2001

6.  A novel augmentation strategy for treating resistant major depression.

Authors:  R C Shelton; G D Tollefson; M Tohen; S Stahl; K S Gannon; T G Jacobs; W R Buras; F P Bymaster; W Zhang; K A Spencer; P D Feldman; H Y Meltzer
Journal:  Am J Psychiatry       Date:  2001-01       Impact factor: 18.112

7.  Methylphenidate augmentation of citalopram in elderly depressed patients.

Authors:  H Lavretsky; A Kumar
Journal:  Am J Geriatr Psychiatry       Date:  2001       Impact factor: 4.105

8.  The significance of depression in older patients after myocardial infarction.

Authors:  Jeanine Romanelli; James A Fauerbach; David E Bush; Roy C Ziegelstein
Journal:  J Am Geriatr Soc       Date:  2002-05       Impact factor: 5.562

9.  Depression predicts increased incidence of adverse health outcomes in older Mexican Americans with type 2 diabetes.

Authors:  Sandra A Black; Kyriakos S Markides; Laura A Ray
Journal:  Diabetes Care       Date:  2003-10       Impact factor: 19.112

10.  The depression care manager and mental health specialist as collaborators within primary care.

Authors:  Thomas E Oxman; Allen J Dietrich; Herbert C Schulberg
Journal:  Am J Geriatr Psychiatry       Date:  2003 Sep-Oct       Impact factor: 4.105
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  9 in total

1.  Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.

Authors:  Eric J Lenze; Benoit H Mulsant; Daniel M Blumberger; Jordan F Karp; John W Newcomer; Stewart J Anderson; Mary Amanda Dew; Meryl A Butters; Jacqueline A Stack; Amy E Begley; Charles F Reynolds
Journal:  Lancet       Date:  2015-09-27       Impact factor: 79.321

Review 2.  Advances in Pharmacotherapy of Late-Life Depression.

Authors:  John L Beyer; Kim G Johnson
Journal:  Curr Psychiatry Rep       Date:  2018-04-07       Impact factor: 5.285

3.  Six-month postintervention depression and disability outcomes of in-home telehealth problem-solving therapy for depressed, low-income homebound older adults.

Authors:  Namkee G Choi; C Nathan Marti; Martha L Bruce; Mark T Hegel; Nancy L Wilson; Mark E Kunik
Journal:  Depress Anxiety       Date:  2014-02-05       Impact factor: 6.505

4.  Predictors and Moderators of Remission With Aripiprazole Augmentation in Treatment-Resistant Late-Life Depression: An Analysis of the IRL-GRey Randomized Clinical Trial.

Authors:  Shriya H Kaneriya; Gregg A Robbins-Welty; Stephen F Smagula; Jordan F Karp; Meryl A Butters; Eric J Lenze; Benoit H Mulsant; Daniel Blumberger; Stewart J Anderson; Mary Amanda Dew; Francis Lotrich; Howard J Aizenstein; Breno S Diniz; Charles F Reynolds
Journal:  JAMA Psychiatry       Date:  2016-04       Impact factor: 21.596

5.  Depression in Homebound Older Adults: Recent Advances in Screening and Psychosocial Interventions.

Authors:  Namkee G Choi; Jo Anne Sirey; Martha L Bruce
Journal:  Curr Transl Geriatr Exp Gerontol Rep       Date:  2012-12-07

6.  Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study.

Authors:  Peng Li; Ing-Tsung Hsiao; Chia-Yih Liu; Chia-Hsiang Chen; She-Yao Huang; Tzu-Chen Yen; Kuan-Yi Wu; Kun-Ju Lin
Journal:  EJNMMI Res       Date:  2017-03-21       Impact factor: 3.138

7.  Depression in the Elderly. Consensus Statement of the Spanish Psychogeriatric Association.

Authors:  Luis Agüera-Ortiz; María Dolores Claver-Martín; María Dolores Franco-Fernández; Jorge López-Álvarez; Manuel Martín-Carrasco; María Isabel Ramos-García; Manuel Sánchez-Pérez
Journal:  Front Psychiatry       Date:  2020-05-20       Impact factor: 4.157

8.  Atypical antipsychotics as add-on treatment in late-life depression.

Authors:  Sibel Cakir; Zeynep Senkal
Journal:  Clin Interv Aging       Date:  2016-09-09       Impact factor: 4.458

9.  Efficacy, acceptability, and safety of adjunctive aripiprazole in treatment-resistant depression: a meta-analysis of randomized controlled trials.

Authors:  Shuxin Luan; Hongquan Wan; Lei Zhang; Hua Zhao
Journal:  Neuropsychiatr Dis Treat       Date:  2018-02-08       Impact factor: 2.570
  9 in total

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