PURPOSE: The purpose of this study was to clarify the gender differences in the prognosis, as well as mortality and morbidity, of patients who have undergone esophagectomy for esophageal cancer. METHODS: The clinical results of esophagectomy were compared between 975 male and 156 female patients with esophageal cancer. RESULTS: The male to female ratios of cervical and thoracic esophageal cancer were 1.87 and 7.38, respectively (P < 0.01). The incidence of preoperative comorbidities was 32.4 and 17.4 %, respectively, and the rates of both tobacco and alcohol abuse were significantly lower in the females than in the males. The mortality rate was lower in the females (3.8 %) than in the males (5.7 %), although the differences were not significant. The overall survival was significantly better in the female than in the male patients (P = 0.039). The 5- and 10-year overall survival rates were 32.6 and 20.5 % in the males and 39.5 and 32.5 % in the females, respectively. A multivariate analysis revealed gender to be an independent prognostic factor. However, no significant differences were recognized in disease-specific survival. CONCLUSIONS: These results suggest that the prognosis of females with esophageal cancer is better than that of males after esophagectomy, most likely due to multiple clinical factors, such as a more favorable lifestyle and general status.
PURPOSE: The purpose of this study was to clarify the gender differences in the prognosis, as well as mortality and morbidity, of patients who have undergone esophagectomy for esophageal cancer. METHODS: The clinical results of esophagectomy were compared between 975 male and 156 female patients with esophageal cancer. RESULTS: The male to female ratios of cervical and thoracic esophageal cancer were 1.87 and 7.38, respectively (P < 0.01). The incidence of preoperative comorbidities was 32.4 and 17.4 %, respectively, and the rates of both tobacco and alcohol abuse were significantly lower in the females than in the males. The mortality rate was lower in the females (3.8 %) than in the males (5.7 %), although the differences were not significant. The overall survival was significantly better in the female than in the male patients (P = 0.039). The 5- and 10-year overall survival rates were 32.6 and 20.5 % in the males and 39.5 and 32.5 % in the females, respectively. A multivariate analysis revealed gender to be an independent prognostic factor. However, no significant differences were recognized in disease-specific survival. CONCLUSIONS: These results suggest that the prognosis of females with esophageal cancer is better than that of males after esophagectomy, most likely due to multiple clinical factors, such as a more favorable lifestyle and general status.
Authors: Lawrence S Engel; Wong-Ho Chow; Thomas L Vaughan; Marilie D Gammon; Harvey A Risch; Janet L Stanford; Janet B Schoenberg; Susan T Mayne; Robert Dubrow; Heidrun Rotterdam; A Brian West; Martin Blaser; William J Blot; Mitchell H Gail; Joseph F Fraumeni Journal: J Natl Cancer Inst Date: 2003-09-17 Impact factor: 13.506
Authors: Tamar B Nobel; Jennifer Livschitz; Mahmoud Eljalby; Yelena Y Janjigian; Manjit S Bains; Prasad S Adusumilli; David R Jones; Daniela Molena Journal: Ann Surg Date: 2020-07 Impact factor: 13.787
Authors: Úna C McMenamin; James Trainor; Helen G Coleman; Damian T McManus; Stephen McQuaid; Victoria Bingham; Jacqueline James; Manuel Salto-Tellez; Brian T Johnston; Richard C Turkington Journal: Oncotarget Date: 2018-10-19
Authors: Marianne C Kalff; Anna D Wagner; Rob H A Verhoeven; Valery E P P Lemmens; Hanneke W M van Laarhoven; Suzanne S Gisbertz; Mark I van Berge Henegouwen Journal: Gastric Cancer Date: 2021-08-07 Impact factor: 7.370