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Literature DB >> 23563730

Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood.

Zheng Zhang¹, Jeffrey Borenstein, Linda Guiney, Raanan Miller, Sivaprasad Sukavaneshvar, Christopher Loose.

Abstract

Assembled polydimethylsiloxane microfluidic devices were modified with a sulfobetaine polymer through continuous "tip-to-tip" modification, significantly reducing blood clotting and extending device patency under blood flow. This technology can be designed to enable the development of devices that can continuously work in whole blood, especially in an extracorporeal or in vivo environment.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 23563730 DOI： 10.1039/c3lc50302j

Source DB: PubMed Journal: Lab Chip ISSN： 1473-0189 Impact factor: 6.799

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Cited

7 in total

1. Development of a biomimetic microfluidic oxygen transfer device.

Authors: A A Gimbel; E Flores; A Koo; G García-Cardeña; J T Borenstein
Journal: Lab Chip Date: 2016-08-16 Impact factor: 6.799

2. Surface modification on polydimethylsiloxane-based microchannels with fragmented poly(l-lactic acid) nanosheets.

Authors: Lu Yang; Yosuke Okamura; Hiroshi Kimura
Journal: Biomicrofluidics Date: 2015-11-20 Impact factor: 2.800

3. A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.

Authors: Daniel C Leslie; Anna Waterhouse; Julia B Berthet; Thomas M Valentin; Alexander L Watters; Abhishek Jain; Philseok Kim; Benjamin D Hatton; Arthur Nedder; Kathryn Donovan; Elana H Super; Caitlin Howell; Christopher P Johnson; Thy L Vu; Dana E Bolgen; Sami Rifai; Anne R Hansen; Michael Aizenberg; Michael Super; Joanna Aizenberg; Donald E Ingber
Journal: Nat Biotechnol Date: 2014-10-12 Impact factor: 54.908

Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood.

1. Development of a biomimetic microfluidic oxygen transfer device.

2. Surface modification on polydimethylsiloxane-based microchannels with fragmented poly(l-lactic acid) nanosheets.

3. A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.

4. A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices.

5. Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics.

6. A Parametric Analysis of Capillary Height in Single-Layer, Small-Scale Microfluidic Artificial Lungs.

7. Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications.