| Literature DB >> 23562578 |
L Zhou1, H Wang, P Wang, H Ren, D Chen, Z Ying, G Wang.
Abstract
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder associated with polyglutamine (polyQ) protein ataxin-3. Ataxin-3 is a multi-functional protein, but the precise mechanisms underlying the cellular functions of ataxin-3 remain to be elucidated. Here we demonstrate that ataxin-3 plays a protective role against cellular oxidative stress induced by H2O2 in a Bcl-XL-dependent manner. Ataxin-3 directly interacts with Bcl-XL. The N-terminus of ataxin-3 and the C-terminus of Bcl-XL are essential for the interaction. Ataxin-3 promotes the interaction between Bcl-XL and Bax, but does not affect the ubiquitination and degradation of Bcl-XL. Our data suggest that ataxin-3 plays an important role in regulating the Bcl-XL-Bax-mediated anti-oxidative response by modulating the interaction between Bcl-XL and Bax.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23562578 DOI： 10.1016/j.neuroscience.2013.03.047
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590