Literature DB >> 23559450

Gastric cancer prevention by demethylation.

Barbara G Schneider1, Richard M Peek.   

Abstract

Niwa and colleagues report in this issue that treatment with the DNA demethylation agent 5-aza-2'-deoxycytidine decreases the incidence of gastric cancers in an animal model of Helicobacter pylori-promoted gastric cancer. This provocative study underscores the importance of changes in DNA methylation that contribute to the origin of inflammation-related cancers. The findings also raise the exciting possibility of cancer prevention by altering DNA methylation events early during tumorigenesis.

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Year:  2013        PMID： 23559450      PMCID： PMC3620723          DOI： 10.1158/1940-6207.CAPR-13-0067

Source DB:  PubMed          Journal:  Cancer Prev Res (Phila)        ISSN： 1940-6215


  31 in total

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Journal:  Cancer Chemother Pharmacol       Date:  2012-10-09       Impact factor: 3.333

2.  Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology.

Authors:  J E Crabtree; J D Taylor; J I Wyatt; R V Heatley; T M Shallcross; D S Tompkins; B J Rathbone
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4.  Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.

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6.  Meta-analysis of the relationship between cagA seropositivity and gastric cancer.

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Journal:  Gastroenterology       Date:  2003-12       Impact factor: 22.682

7.  8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.

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8.  Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent.

Authors:  Tohru Niwa; Takeshi Toyoda; Tetsuya Tsukamoto; Akiko Mori; Masae Tatematsu; Toshikazu Ushijima
Journal:  Cancer Prev Res (Phila)       Date:  2013-04

9.  Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer.

Authors:  A O-O Chan; S-K Lam; B C-Y Wong; W-M Wong; M-F Yuen; Y-H Yeung; W-M Hui; A Rashid; Y-L Kwong
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  3 in total

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2.  Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells.

Authors:  Yun-feng Lou; Zheng-zhi Zou; Pin-jia Chen; Guo-bin Huang; Bin Li; De-qing Zheng; Xiu-rong Yu; Xiao-yong Luo
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3.  Amide-type local anesthetics may suppress tumor cell proliferation and sensitize Human Hepatocellular Carcinoma Cells to Cisplatin via upregulation of RASSF1A expression and demethylation.

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  3 in total

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