Literature DB >> 12775840

Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.

Manuel R Amieva1, Roger Vogelmann, Antonello Covacci, Lucy S Tompkins, W James Nelson, Stanley Falkow.   

Abstract

Helicobacter pylori translocates the protein CagA into gastric epithelial cells and has been linked to peptic ulcer disease and gastric carcinoma. We show that injected CagA associates with the epithelial tight-junction scaffolding protein ZO-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex. Long-term CagA delivery to polarized epithelia caused a disruption of the epithelial barrier function and dysplastic alterations in epithelial cell morphology. CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions.

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Year:  2003        PMID： 12775840      PMCID： PMC3369828          DOI： 10.1126/science.1081919

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

1.  Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.

Authors:  S Odenbreit; J Püls; B Sedlmaier; E Gerland; W Fischer; R Haas
Journal:  Science       Date:  2000-02-25       Impact factor: 47.728

2.  SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Authors:  Hideaki Higashi; Ryouhei Tsutsumi; Syuichi Muto; Toshiro Sugiyama; Takeshi Azuma; Masahiro Asaka; Masanori Hatakeyama
Journal:  Science       Date:  2001-12-13       Impact factor: 47.728

Review 3.  Intercellular adhesion, signalling and the cytoskeleton.

Authors:  Colin Jamora; Elaine Fuchs
Journal:  Nat Cell Biol       Date:  2002-04       Impact factor: 28.824

4.  Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation.

Authors:  M Stein; R Rappuoli; A Covacci
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

5.  Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8.

Authors:  W Fischer; J Püls; R Buhrdorf; B Gebert; S Odenbreit; R Haas
Journal:  Mol Microbiol       Date:  2001-12       Impact factor: 3.501

6.  Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori.

Authors:  E D Segal; J Cha; J Lo; S Falkow; L S Tompkins
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

7.  Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

Authors:  D Bilder; M Li; N Perrimon
Journal:  Science       Date:  2000-07-07       Impact factor: 47.728

8.  c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.

Authors:  Markus Stein; Fabio Bagnoli; Robert Halenbeck; Rino Rappuoli; Wendy J Fantl; Antonello Covacci
Journal:  Mol Microbiol       Date:  2002-02       Impact factor: 3.501

9.  Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells.

Authors:  C Yeaman; K K Grindstaff; J R Wright; W J Nelson
Journal:  J Cell Biol       Date:  2001-11-05       Impact factor: 10.539

10.  Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

Authors:  Viyada Nunbhakdi-Craig; Thomas Machleidt; Egon Ogris; Dennis Bellotto; Charles L White; Estelle Sontag
Journal:  J Cell Biol       Date:  2002-08-26       Impact factor: 10.539
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  300 in total

1.  Life at the margins: modulation of attachment proteins in Helicobacter pylori.

Authors:  Mary E Moore; Thomas Borén; Jay V Solnick
Journal:  Gut Microbes       Date:  2011 Jan-Feb

2.  JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration.

Authors:  Ke Zen; Brian A Babbin; Yuan Liu; John B Whelan; Asma Nusrat; Charles A Parkos
Journal:  Mol Biol Cell       Date:  2004-06-11       Impact factor: 4.138

3.  Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways.

Authors:  Stefan Moese; Matthias Selbach; Terry Kwok; Volker Brinkmann; Wolfgang König; Thomas F Meyer; Steffen Backert
Journal:  Infect Immun       Date:  2004-06       Impact factor: 3.441

Review 4.  The versatile bacterial type IV secretion systems.

Authors:  Eric Cascales; Peter J Christie
Journal:  Nat Rev Microbiol       Date:  2003-11       Impact factor: 60.633

Review 5.  Breaking into the epithelial apical-junctional complex--news from pathogen hackers.

Authors:  Roger Vogelmann; Manuel R Amieva; Stanley Falkow; W James Nelson
Journal:  Curr Opin Cell Biol       Date:  2004-02       Impact factor: 8.382

Review 6.  The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis.

Authors:  Masahiko Itoh; Mina J Bissell
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-10       Impact factor: 2.673

Review 7.  Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease.

Authors:  Dacie R Bridge; D Scott Merrell
Journal:  Gut Microbes       Date:  2013-02-04

Review 8.  Exploring alternative treatments for Helicobacter pylori infection.

Authors:  Guadalupe Ayala; Wendy Itzel Escobedo-Hinojosa; Carlos Felipe de la Cruz-Herrera; Irma Romero
Journal:  World J Gastroenterol       Date:  2014-02-14       Impact factor: 5.742

Review 9.  Pathobiology of Helicobacter pylori-Induced Gastric Cancer.

Authors:  Manuel Amieva; Richard M Peek
Journal:  Gastroenterology       Date:  2015-09-16       Impact factor: 22.682

10.  The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA.

Authors:  Daniel A Bonsor; Qing Zhao; Barbara Schmidinger; Evelyn Weiss; Jingheng Wang; Daniel Deredge; Robert Beadenkopf; Blaine Dow; Wolfgang Fischer; Dorothy Beckett; Patrick L Wintrode; Rainer Haas; Eric J Sundberg
Journal:  EMBO J       Date:  2018-05-03       Impact factor: 11.598
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