Literature DB >> 23559154

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe.

Ka-Ho Leung1, Hong-Zhang He, Victor Pui-Yan Ma, Hai-Jing Zhong, Daniel Shiu-Hin Chan, Jun Zhou, Jean-Louis Mergny, Chung-Hang Leung, Dik-Lung Ma.   

Abstract

We report herein a simple and convenient luminescent assay for detection of base excision repair enzyme activity using an Ir(III) complex as a G-quadruplex selective probe. Using uracil-DNA glycosylase (UDG) as a model enzyme, the assay achieved high sensitivity and selectivity for UDG over other tested enzymes. The utility of the assay for screening potential UDG inhibitors was also demonstrated.

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Year:  2013        PMID： 23559154     DOI： 10.1039/c3cc41129j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  A tetrahedral DNA nanoflare for fluorometric determination of nucleic acids and imaging of microRNA using toehold strands.

Authors:  Liang Li; Yingcai Meng; Ling Li; Shengfeng Wang; Jinsong Ding; Wenhu Zhou
Journal:  Mikrochim Acta       Date:  2019-11-21       Impact factor: 5.833

2.  Synthesis, labeling and bioanalytical applications of a tris(2,2'-bipyridyl)ruthenium(II)-based electrochemiluminescence probe.

Authors:  Xiaoming Zhou; Debin Zhu; Yuhui Liao; Weipeng Liu; Hongxing Liu; Zhaokui Ma; Da Xing
Journal:  Nat Protoc       Date:  2014-04-17       Impact factor: 13.491

Review 3.  Fluorescent Probes of DNA Repair.

Authors:  David L Wilson; Eric T Kool
Journal:  ACS Chem Biol       Date:  2017-11-30       Impact factor: 5.100

4.  Cyclometalated rhodium and iridium complexes with imidazole containing Schiff bases: Synthesis, structure and cellular imaging.

Authors:  Soumik Mandal; Dipak K Poria; Dipravath K Seth; Partho Sarothi Ray; Parna Gupta
Journal:  Polyhedron       Date:  2014-02-10       Impact factor: 3.052

5.  A label-free luminescent switch-on assay for ATP using a G-quadruplex-selective iridium(III) complex.

Authors:  Ka-Ho Leung; Lihua Lu; Modi Wang; Tsun-Yin Mak; Daniel Shiu-Hin Chan; Fung-Kit Tang; Chung-Hang Leung; Hiu-Yee Kwan; Zhiling Yu; Dik-Lung Ma
Journal:  PLoS One       Date:  2013-10-25       Impact factor: 3.240

6.  A colorimetric and luminescent dual-modal assay for Cu(II) ion detection using an iridium(III) complex.

Authors:  Dik-Lung Ma; Hong-Zhang He; Daniel Shiu-Hin Chan; Chun-Yuen Wong; Chung-Hang Leung
Journal:  PLoS One       Date:  2014-06-13       Impact factor: 3.240

7.  A ruthenium(II) complex supported by trithiacyclononane and aromatic diimine ligand as luminescent switch-on probe for biomolecule detection and protein staining.

Authors:  Chun-Yuen Wong; Lai-Hon Chung; Sheng Lin; Daniel Shiu-Hin Chan; Chung-Hang Leung; Dik-Lung Ma
Journal:  Sci Rep       Date:  2014-11-20       Impact factor: 4.379

8.  A colorimetric chemosensor for Cu²⁺ ion detection based on an iridium(III) complex.

Authors:  Modi Wang; Ka-Ho Leung; Sheng Lin; Daniel Shiu-Hin Chan; Daniel W J Kwong; Chung-Hang Leung; Dik-Lung Ma
Journal:  Sci Rep       Date:  2014-10-28       Impact factor: 4.379

Review 9.  Organoiridium complexes: anticancer agents and catalysts.

Authors:  Zhe Liu; Peter J Sadler
Journal:  Acc Chem Res       Date:  2014-02-20       Impact factor: 22.384

10.  Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine.

Authors:  Lihua Lu; Hai-Jing Zhong; Bingyong He; Chung-Hang Leung; Dik-Lung Ma
Journal:  Sci Rep       Date:  2016-01-18       Impact factor: 4.379
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