OBJECTIVE: This systematic review was conducted to synthesize the existing evidence regarding key considerations influencing African Americans' participation in cancer clinical trials (CCTs). METHODS: The PubMed and PsycINFO databases were searched to identify peer-reviewed publications during the last decade (2002-2011) that met our inclusionary criteria. Our search utilized Boolean combinations of the following terms: "clinical trial"; "cancer"; "neoplasm"; "African American"; "Black"; "caregiver"; "decision making"; "recruitment"; "companion"; "family"; "significant other"; and "social support". RESULTS: A total of 267 articles were identified in the database searches. Of these articles, a total of 31 were determined to meet the inclusion criteria and were retained for review. Key issues that emerged as impediments to a successful recruitment of African Americans to CCTs included negative attitudes towards clinical trials, low levels of knowledge and awareness regarding CCTs, religious beliefs, and structural barriers, such as transportation, childcare, and access to health care. Recommendations from physicians, family members, and friends may promote CCT participation. Multimedia, and culturally-appropriate recruitment approaches may also be effective in soliciting participation among African Americans. CONCLUSION: Existing research underscores the importance of social support from family and friends, cultural appropriateness and sensitivity from physicians and in the design of the CCT, and enhanced education among African Americans in decision-making processes. As African Americans are underrepresented in CCTs, targeted strategies to enhance recruitment efforts and improve cancer treatment outcomes are essential. Published by Elsevier Inc.
OBJECTIVE: This systematic review was conducted to synthesize the existing evidence regarding key considerations influencing African Americans' participation in cancer clinical trials (CCTs). METHODS: The PubMed and PsycINFO databases were searched to identify peer-reviewed publications during the last decade (2002-2011) that met our inclusionary criteria. Our search utilized Boolean combinations of the following terms: "clinical trial"; "cancer"; "neoplasm"; "African American"; "Black"; "caregiver"; "decision making"; "recruitment"; "companion"; "family"; "significant other"; and "social support". RESULTS: A total of 267 articles were identified in the database searches. Of these articles, a total of 31 were determined to meet the inclusion criteria and were retained for review. Key issues that emerged as impediments to a successful recruitment of African Americans to CCTs included negative attitudes towards clinical trials, low levels of knowledge and awareness regarding CCTs, religious beliefs, and structural barriers, such as transportation, childcare, and access to health care. Recommendations from physicians, family members, and friends may promote CCT participation. Multimedia, and culturally-appropriate recruitment approaches may also be effective in soliciting participation among African Americans. CONCLUSION: Existing research underscores the importance of social support from family and friends, cultural appropriateness and sensitivity from physicians and in the design of the CCT, and enhanced education among African Americans in decision-making processes. As African Americans are underrepresented in CCTs, targeted strategies to enhance recruitment efforts and improve cancer treatment outcomes are essential. Published by Elsevier Inc.
Entities:
Keywords:
AA; African American; African Americans; Blacks; CCT; Cancer clinical trials; Education; Recruitment; Social support; cancer clinical trial
Authors: Soumya J Niranjan; Raegan W Durant; Jennifer A Wenzel; Elise D Cook; Mona N Fouad; Selwyn M Vickers; Badrinath R Konety; Sarah B Rutland; Zachary R Simoni; Michelle Y Martin Journal: J Cancer Educ Date: 2019-02 Impact factor: 2.037
Authors: Anita Kurt; Lauren Semler; Jeanne L Jacoby; Melanie B Johnson; Beth A Careyva; Brian Stello; Timothy Friel; Mark C Knouse; Hope Kincaid; John C Smulian Journal: J Racial Ethn Health Disparities Date: 2016-09-08
Authors: Dionna O Roberts; Brittany Covert; Mark J Rodeghier; Nagina Parmar; Michael R DeBaun; Alexis A Thompson; Robert I Liem Journal: Pediatr Blood Cancer Date: 2014-04-22 Impact factor: 3.167
Authors: Melissa A Green; Margo Michaels; Natasha Blakeney; Adebowale A Odulana; Malika Roman Isler; Alan Richmond; Debra G Long; William S Robinson; Yhenneko J Taylor; Giselle Corbie-Smith Journal: J Cancer Educ Date: 2015-03 Impact factor: 2.037
Authors: Robert L Newton; William D Johnson; Chelsea Hendrick; Melissa Harris; Emanuel Andrews; Neil Johannsen; Ruben Q Rodarte; Daniel S Hsia; Timothy S Church Journal: Contemp Clin Trials Date: 2015-05-12 Impact factor: 2.226
Authors: Amanda Ritchie; Marya Viorst Gwadz; David Perlman; Rebecca De Guzman; Noelle R Leonard; Charles M Cleland Journal: J AIDS Clin Res Date: 2016-12-29
Authors: Laura C Bouchard; Betina Yanez; Jason R Dahn; Sarah C Flury; Kent T Perry; David C Mohr; Frank J Penedo Journal: Transl Behav Med Date: 2019-07-16 Impact factor: 3.046
Authors: S Manne; D Kashy; T Albrecht; Y-N Wong; A Lederman Flamm; A B Benson; S M Miller; Linda Fleisher; J Buzaglo; N Roach; M Katz; E Ross; M Collins; D Poole; S Raivitch; D M Miller; T G Kinzy; T Liu; N J Meropol Journal: Eur J Cancer Care (Engl) Date: 2014-01-28 Impact factor: 2.520