Christos Sidiropoulos1, William Hutchison, Tiago Mestre, Elena Moro, Ian A Prescott, Alejandro Valencia Mizrachi, Melanie Fallis, Anand I Rughani, Suneil K Kalia, Andres Lozano, Susan Fox.
Abstract
BACKGROUND: To report on the clinical efficacy of bilateral globus pallidus internus deep brain stimulation in a 29-year-old patient with severe generalized dystonia secondary to Wilson's disease.
METHODS: The primary outcome measure was the Burke-Fahn-Marsden Dystonia Scale motor severity score (blinded assessment) and the secondary outcome measures were the Abnormal Involuntary Movement Scale (blinded assessment) and the Zaritt Caregiver Burden Interview score, at 20-week postoperative follow up.
RESULTS: There was a 14% improvement in the Burke-Fahn-Marsden Dystonia Scale motor severity score. Abnormal Involuntary Movement Scale score remained unchanged while the Zaritt Caregiver Burden Interview score improved by 44.4%.
CONCLUSIONS: Bilateral globus pallidus deep brain stimulation can be effective in ameliorating dystonia and caregiver burden in Wilson's disease. Outcomes may depend on the stage of the disease at which the surgical procedure is completed. © 2013 Movement Disorder Society.
BACKGROUND: To report on the clinical efficacy of bilateral globus pallidus internus deep brain stimulation in a 29-year-old patient with severe generalized dystonia secondary to Wilson's disease.
METHODS: The primary outcome measure was the Burke-Fahn-Marsden Dystonia Scale motor severity score (blinded assessment) and the secondary outcome measures were the Abnormal Involuntary Movement Scale (blinded assessment) and the Zaritt Caregiver Burden Interview score, at 20-week postoperative follow up.
RESULTS: There was a 14% improvement in the Burke-Fahn-Marsden Dystonia Scale motor severity score. Abnormal Involuntary Movement Scale score remained unchanged while the Zaritt Caregiver Burden Interview score improved by 44.4%.
CONCLUSIONS: Bilateral globus pallidus deep brain stimulation can be effective in ameliorating dystonia and caregiver burden in Wilson's disease. Outcomes may depend on the stage of the disease at which the surgical procedure is completed. © 2013 Movement Disorder Society.
Copyright © 2013 Movement Disorder Society.
Entities:
Keywords:
Wilson's disease; deep brain stimulation; globus pallidus
Mesh：
Year: 2013
PMID： 23554137 DOI： 10.1002/mds.25446
Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338