Literature DB >> 23551888

FOXO4 is necessary for neural differentiation of human embryonic stem cells.

David Vilchez1, Leah Boyer, Margaret Lutz, Carsten Merkwirth, Ianessa Morantte, Chris Tse, Brian Spencer, Lesley Page, Eliezer Masliah, William Travis Berggren, Fred H Gage, Andrew Dillin.   

Abstract

Proteostasis is critical for maintaining cell function and proteome stability may play an important role in human embryonic stem cell (hESC) immortality. Notably, hESC populations exhibit a high assembly of active proteasomes, a key node of the proteostasis network. FOXO4, an insulin/IGF-1 responsive transcription factor, regulates proteasome activity in hESCs. We find that loss of FOXO4 reduces the potential of hESCs to differentiate into neural lineages. Therefore, FOXO4 crosses evolutionary boundaries and links hESC function to invertebrate longevity modulation.

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Year:  2013        PMID： 23551888      PMCID： PMC4864013          DOI： 10.1111/acel.12067

Source DB:  PubMed          Journal:  Aging Cell        ISSN： 1474-9718            Impact factor:   9.304


  17 in total

Review 1.  The plasticity of aging: insights from long-lived mutants.

Authors:  Cynthia Kenyon
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

2.  Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.

Authors:  David Vilchez; Leah Boyer; Ianessa Morantte; Margaret Lutz; Carsten Merkwirth; Derek Joyce; Brian Spencer; Lesley Page; Eliezer Masliah; W Travis Berggren; Fred H Gage; Andrew Dillin
Journal:  Nature       Date:  2012-09-13       Impact factor: 49.962

3.  FoxO6 regulates memory consolidation and synaptic function.

Authors:  Dervis A M Salih; Asim J Rashid; Damien Colas; Luis de la Torre-Ubieta; Ruo P Zhu; Alexander A Morgan; Evan E Santo; Duygu Ucar; Keerthana Devarajan; Christina J Cole; Daniel V Madison; Mehrdad Shamloo; Atul J Butte; Azad Bonni; Sheena A Josselyn; Anne Brunet
Journal:  Genes Dev       Date:  2012-12-07       Impact factor: 11.361

4.  Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family.

Authors:  Hidenori Matsuzaki; Akira Ichino; Tadahiro Hayashi; Toshiyoshi Yamamoto; Ushio Kikkawa
Journal:  J Biochem       Date:  2005-10       Impact factor: 3.387

5.  An mRNA splice variant of the AFX gene with altered transcriptional activity.

Authors:  Zhenyu Yang; James Whelan; Robert Babb; Benjamin R Bowen
Journal:  J Biol Chem       Date:  2002-01-04       Impact factor: 5.157

6.  DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.

Authors:  Hien Tran; Anne Brunet; Jill M Grenier; Sandeep R Datta; Albert J Fornace; Peter S DiStefano; Lillian W Chiang; Michael E Greenberg
Journal:  Science       Date:  2002-04-19       Impact factor: 47.728

Review 7.  Biological and chemical approaches to diseases of proteostasis deficiency.

Authors:  Evan T Powers; Richard I Morimoto; Andrew Dillin; Jeffery W Kelly; William E Balch
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

8.  FOXO3A genotype is strongly associated with human longevity.

Authors:  Bradley J Willcox; Timothy A Donlon; Qimei He; Randi Chen; John S Grove; Katsuhiko Yano; Kamal H Masaki; D Craig Willcox; Beatriz Rodriguez; J David Curb
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-02       Impact factor: 11.205

9.  Embryonic stem cell lines derived from human blastocysts.

Authors:  J A Thomson; J Itskovitz-Eldor; S S Shapiro; M A Waknitz; J J Swiergiel; V S Marshall; J M Jones
Journal:  Science       Date:  1998-11-06       Impact factor: 47.728

10.  RPN-6 determines C. elegans longevity under proteotoxic stress conditions.

Authors:  David Vilchez; Ianessa Morantte; Zheng Liu; Peter M Douglas; Carsten Merkwirth; Ana P C Rodrigues; Gerard Manning; Andrew Dillin
Journal:  Nature       Date:  2012-09-13       Impact factor: 49.962
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  17 in total

Review 1.  Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.

Authors:  Alireza Noormohammadi; Giuseppe Calculli; Ricardo Gutierrez-Garcia; Amirabbas Khodakarami; Seda Koyuncu; David Vilchez
Journal:  Cell Mol Life Sci       Date:  2017-07-26       Impact factor: 9.261

Review 2.  FOXO transcription factors: key regulators of cellular quality control.

Authors:  Ashley E Webb; Anne Brunet
Journal:  Trends Biochem Sci       Date:  2014-03-13       Impact factor: 13.807

3.  Enhanced self-renewal of human pluripotent stem cells by simulated microgravity.

Authors:  S Timilsina; T Kirsch-Mangu; S Werth; B Shepard; T Ma; L G Villa-Diaz
Journal:  NPJ Microgravity       Date:  2022-07-04       Impact factor: 4.970

4.  Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity.

Authors:  Hong Yao; Minghui Liu; Leibo Wang; Yumeng Zu; Chou Wu; Chenyu Li; Ruoxi Zhang; Haigen Lu; Feifei Li; Shuang Xi; Shuangquan Chen; Xuanyu Gu; Tianya Liu; Jie Cai; Shirong Wang; Maojun Yang; Guo-Gang Xing; Wei Xiong; Lan Hua; Yefeng Tang; Gelin Wang
Journal:  Cell Res       Date:  2022-04-22       Impact factor: 46.297

Review 5.  Metabolic circuits in neural stem cells.

Authors:  Do-Yeon Kim; Inmoo Rhee; Jihye Paik
Journal:  Cell Mol Life Sci       Date:  2014-07-19       Impact factor: 9.261

6.  FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis.

Authors:  Ashley E Webb; Elizabeth A Pollina; Thomas Vierbuchen; Noelia Urbán; Duygu Ucar; Dena S Leeman; Ben Martynoga; Madhavi Sewak; Thomas A Rando; François Guillemot; Marius Wernig; Anne Brunet
Journal:  Cell Rep       Date:  2013-07-25       Impact factor: 9.423

7.  Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells.

Authors:  Jiwon Jang; Yidi Wang; Hyung-Seok Kim; Matthew A Lalli; Kenneth S Kosik
Journal:  Stem Cells       Date:  2014-10       Impact factor: 6.277

8.  MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex.

Authors:  Wei Zhang; Paul Jong Kim; Zhongcan Chen; Hidayat Lokman; Lifeng Qiu; Ke Zhang; Steven George Rozen; Eng King Tan; Hyunsoo Shawn Je; Li Zeng
Journal:  Elife       Date:  2016-02-17       Impact factor: 8.140

9.  The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.

Authors:  Isabel Saez; David Vilchez
Journal:  Curr Genomics       Date:  2014-02       Impact factor: 2.236

10.  AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation.

Authors:  Yunbo Qiao; Xiongjun Wang; Ran Wang; Yuanyuan Li; Fang Yu; Xianfa Yang; Lu Song; Guoliang Xu; Y Eugene Chin; Naihe Jing
Journal:  Cell Discov       Date:  2015-07-28       Impact factor: 10.849
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