Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Phosphoinositide 3-kinase and INPP4B in human breast cancer.

Literature DB >> 23551093

Phosphoinositide 3-kinase and INPP4B in human breast cancer.

Micka C Bertucci¹, Christina A Mitchell.

Abstract

The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cancer. Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor suppressor in breast cancer. This short review discusses these issues and the possibility that INPP4B is an important regulator in many cancers.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23551093 DOI： 10.1111/nyas.12036

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

Keyword Cloud
Cited

19 in total

1. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.

Authors: Ruth Perets; Gregory A Wyant; Katherine W Muto; Jonathan G Bijron; Barish B Poole; Kenneth T Chin; Jin Yun H Chen; Anders W Ohman; Corey D Stepule; Soongu Kwak; Alison M Karst; Michelle S Hirsch; Sunita R Setlur; Christopher P Crum; Daniela M Dinulescu; Ronny Drapkin
Journal: Cancer Cell Date: 2013-12-09 Impact factor: 31.743

2. Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.

Authors: Petra den Hollander; Kathryn Rawls; Anna Tsimelzon; Jonathan Shepherd; Abhijit Mazumdar; Jamal Hill; Suzanne A W Fuqua; Jenny C Chang; C Kent Osborne; Susan G Hilsenbeck; Gordon B Mills; Powel H Brown
Journal: Cancer Res Date: 2016-02-26 Impact factor: 12.701

3. INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.

Authors: Ying Sun; Huan Ding; Xinguang Liu; Xiaoqing Li; Li Li
Journal: Tumour Biol Date: 2014-01-14

4. The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.

Authors: Ognian C Ikonomov; Catherine Filios; Diego Sbrissa; Xuequn Chen; Assia Shisheva
Journal: Biochem Biophys Res Commun Date: 2013-09-23 Impact factor: 3.575

Phosphoinositide 3-kinase and INPP4B in human breast cancer.

1. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.

2. Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.

3. INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.

4. The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.

Review 5. The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.

Review 6. Breast Cancer Genomics: Primary and Most Common Metastases.

7. INPP4B-mediated DNA repair pathway confers resistance to chemotherapy in acute myeloid leukemia.

Review 8. The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers.

Review 9. Discovery and development of small molecule SHIP phosphatase modulators.

Review 10. Targeting SHIP1 and SHIP2 in Cancer.