| Literature DB >> 24332043 |
Ruth Perets1, Gregory A Wyant2, Katherine W Muto2, Jonathan G Bijron3, Barish B Poole2, Kenneth T Chin2, Jin Yun H Chen2, Anders W Ohman2, Corey D Stepule2, Soongu Kwak1, Alison M Karst1, Michelle S Hirsch3, Sunita R Setlur2, Christopher P Crum3, Daniela M Dinulescu4, Ronny Drapkin5.
Abstract
High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site, recent studies suggest that there may be additional sites of origin outside the ovary, namely the secretory cells of the fallopian tube. Our study demonstrates that high-grade serous tumors can originate in fallopian tubal secretory epithelial cells and also establishes serous tubal intraepithelial carcinoma as the precursor lesion to high-grade serous ovarian and peritoneal carcinomas in animal models targeting the Brca, Tp53, and Pten genes. These findings offer an avenue to address clinically important questions that are critical for cancer prevention and early detection in women carrying BRCA1 and BRCA2 mutations.Entities:
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Year: 2013 PMID： 24332043 PMCID： PMC3917315 DOI： 10.1016/j.ccr.2013.10.013
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743