Literature DB >> 23550817

A short, organocatalytic formal synthesis of (-)-swainsonine and related alkaloids.

Vijay Dhand1, Jason A Draper, Jarod Moore, Robert Britton.   

Abstract

A short synthesis of hydroxyalkyl dihydropyrroles has been developed that involves the coupling of propargylamines with α-chloroaldehydes, followed by Lindlar reduction and a one-pot epoxide formation/opening sequence. The application of this process to the synthesis of unnatural iminosugars and a formal synthesis of (-)-swainsonine is described.

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Year:  2013        PMID： 23550817     DOI： 10.1021/ol400566j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

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Review 5.  Metal-mediated synthesis of pyrrolines.

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  5 in total

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