OBJECTIVE: To examine the responsiveness of generic and condition-specific instruments based on the anchor of self-reported level of global change in patients with colorectal cancer (CRC). STUDY DESIGN AND SETTING: Three hundred thirty-three patients with CRC were surveyed at two assessments at baseline and follow-up at 6 months from September 2009 to July 2010 using the Short Form-12 Health Survey version 2 (SF-12v2) and Functional Assessment of Cancer Therapy-Colorectal (FACT-C) measures. The responsiveness of the two measures was evaluated using standardized effect size, standardized response mean, responsiveness statistic, and receiver operating characteristic (ROC) curve analysis. RESULTS: In worsened group, internal responsiveness of detecting negative changes was satisfactory for most subscales of FACT-C and SF-12v2. The FACT-C subscales were significantly more responsive to positive changes detection than the SF-12v2 subscales in improved group. Physical well-being subscale, Trial Outcome Index (TOI), and total score of FACT-C were more externally responsive to ROC curve analysis. The FACT-C measure was generally more responsive to changes in health status compared with SF-12v2 measure. CONCLUSION: TOI and total score of FACT-C were the most responsive among subscales of condition-specific measure, which were more responsive than all generic subscales with the exception of social domain. Complementary use of condition-specific and generic instruments to evaluate the health-related quality of life of CRC patients is encouraged.
OBJECTIVE: To examine the responsiveness of generic and condition-specific instruments based on the anchor of self-reported level of global change in patients with colorectal cancer (CRC). STUDY DESIGN AND SETTING: Three hundred thirty-three patients with CRC were surveyed at two assessments at baseline and follow-up at 6 months from September 2009 to July 2010 using the Short Form-12 Health Survey version 2 (SF-12v2) and Functional Assessment of Cancer Therapy-Colorectal (FACT-C) measures. The responsiveness of the two measures was evaluated using standardized effect size, standardized response mean, responsiveness statistic, and receiver operating characteristic (ROC) curve analysis. RESULTS: In worsened group, internal responsiveness of detecting negative changes was satisfactory for most subscales of FACT-C and SF-12v2. The FACT-C subscales were significantly more responsive to positive changes detection than the SF-12v2 subscales in improved group. Physical well-being subscale, Trial Outcome Index (TOI), and total score of FACT-C were more externally responsive to ROC curve analysis. The FACT-C measure was generally more responsive to changes in health status compared with SF-12v2 measure. CONCLUSION: TOI and total score of FACT-C were the most responsive among subscales of condition-specific measure, which were more responsive than all generic subscales with the exception of social domain. Complementary use of condition-specific and generic instruments to evaluate the health-related quality of life of CRC patients is encouraged.
Authors: Edmond P H Choi; Carlos K H Wong; Eric Y F Wan; James H L Tsu; W Y Chin; Kenny Kung; M K Yiu Journal: Qual Life Res Date: 2016-02-23 Impact factor: 4.147
Authors: Eric Yuk Fai Wan; Edmond Pui Hang Choi; Esther Yee Tak Yu; Weng Yee Chin; Colman Siu Cheung Fung; Anca Ka Chun Chan; Cindy Lo Kuen Lam Journal: Qual Life Res Date: 2018-06-13 Impact factor: 4.147
Authors: Edmond P H Choi; Carlos K H Wong; James H L Tsu; W Y Chin; Kenny Kung; Charles K W Wong; M K Yiu Journal: Support Care Cancer Date: 2015-10-09 Impact factor: 3.603
Authors: Cindy L K Lam; Esther Y T Yu; Yvonne Y C Lo; Carlos K H Wong; Stewart M Mercer; Daniel Y T Fong; Albert Lee; Tai Pong Lam; Gabriel M Leung Journal: Front Med (Lausanne) Date: 2014-09-15