BACKGROUND: Manganese (Mn) is an essential element and a potential toxicant for developing organism. Deficiency and excess of it were both deleterious to fetal growth in experimental animals. However, literature on relationship between Mn status and birth outcome in humans is sparse. METHODS: Mn concentrations were measured in mother whole blood (MWB) and umbilical cord blood (UCB) in 125 pairs of mother-infant; birth size was examined and relationship between them was analysed. Potentially environmental factors influencing Mn loads in maternal and fetal organisms were investigated through epidemiological method. RESULTS: Mn level in UCB was significantly higher than that in MWB (mean value: 54.98 vs. 78.75 µg/L), and a significant positive correlation was shown between them. There was a quadratic curvilinear (inverted U-shaped curve) relationship between MWB Mn and birth size, and between UCB Mn and birth size. Both univariate analysis and multiple linear regression analysis showed that exposure to harmful occupational factors during gestation remarkably increased maternal and fetal Mn levels. Living close to major transportation routes (<500 m) also increased the MWB Mn levels. CONCLUSION: Our results suggested that lower or higher Mn level in maternal and umbilical blood may induce adverse effect on birth size in humans. In addition, increased levels of Mn in MWB or UCB may be associated with exposure to some environmental hazard factors.
BACKGROUND:Manganese (Mn) is an essential element and a potential toxicant for developing organism. Deficiency and excess of it were both deleterious to fetal growth in experimental animals. However, literature on relationship between Mn status and birth outcome in humans is sparse. METHODS: Mn concentrations were measured in mother whole blood (MWB) and umbilical cord blood (UCB) in 125 pairs of mother-infant; birth size was examined and relationship between them was analysed. Potentially environmental factors influencing Mn loads in maternal and fetal organisms were investigated through epidemiological method. RESULTS: Mn level in UCB was significantly higher than that in MWB (mean value: 54.98 vs. 78.75 µg/L), and a significant positive correlation was shown between them. There was a quadratic curvilinear (inverted U-shaped curve) relationship between MWB Mn and birth size, and between UCB Mn and birth size. Both univariate analysis and multiple linear regression analysis showed that exposure to harmful occupational factors during gestation remarkably increased maternal and fetal Mn levels. Living close to major transportation routes (<500 m) also increased the MWB Mn levels. CONCLUSION: Our results suggested that lower or higher Mn level in maternal and umbilical blood may induce adverse effect on birth size in humans. In addition, increased levels of Mn in MWB or UCB may be associated with exposure to some environmental hazard factors.
Authors: Allison Kupsco; Marco Sanchez-Guerra; Chitra Amarasiriwardena; Kasey J M Brennan; Guadalupe Estrada-Gutierrez; Katherine Svensson; Lourdes Schnaas; Ivan Pantic; Martha María Téllez-Rojo; Andrea A Baccarelli; Robert O Wright Journal: Environ Int Date: 2019-03-05 Impact factor: 9.621
Authors: Jennifer Z J Maccani; Devin C Koestler; E Andrés Houseman; David A Armstrong; Carmen J Marsit; Karl T Kelsey Journal: Reprod Toxicol Date: 2015-05-15 Impact factor: 3.143
Authors: Ema G Rodrigues; Molly Kile; Christine Dobson; Chitra Amarasiriwardena; Quazi Quamruzzaman; Mahmuder Rahman; Mostofa Golam; David C Christiani Journal: J Expo Sci Environ Epidemiol Date: 2015-08-26 Impact factor: 5.563